Skip to Content
Merck

F8927

Flupirtine maleate salt

≥98% (HPLC)

Synonym(s):

2-Amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-carbamic acid ethyl ester maleate salt

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C15H17FN4O2 · C4H4O4
CAS Number:
75507-68-5
Molecular Weight:
420.39
NACRES:
NA.77
PubChem Substance ID:
24278445
UNSPSC Code:
12352200
MDL number:
MFCD00941415
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

DPYIXBFZUMCMJM-BTJKTKAUSA-N

SMILES string

OC(=O)\C=C/C(O)=O.CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N

InChI

1S/C15H17FN4O2.C4H4O4/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10;5-3(6)1-2-4(7)8/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20);1-2H,(H,5,6)(H,7,8)/b;2-1-

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble >20 mg/mL, H2O: insoluble

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Flupirtine is commercially available as maleate salt. It exists in two polymorphs : flupirtine maleate A and B. Flupirtine is useful in treating muscular spasm, muscle tension and muscle stiffness. It is known to be effective in relieving back pain. Along with cytoprotection, flupirtine also offers protection against neurodegenerative disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer′s disease, Parkinson′s disease, Huntington′s chorea and AID (acquired immunodeficiency) associated encephalopathy. Flupirtine is found to be a potential drug for eye-related problems like maculopathy including diabetic retinopathy, retinitis pigmentosa and glaucoma. It is also proved to be helpful in preventing cardiac associated disorders such as myocardial ischemia and infarction, cerebral ischemia and infarction. Hepatitis is also prevented by the use of flupirtine.
Non-opioid analgesic; cytoprotective versus PrP fragment 106-126

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000507068
0000507067
0000507067
0000507068
0000423902

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Istvan Szelenyi
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 62(3), 251-258 (2013-01-17)
Flupirtine was developed long before K(V)7 (KCNQ) channels were known. However, it was clear from the beginning that flupirtine is neither an opioid nor a nonsteroidal anti-inflammatory analgesic. Its unique muscle relaxing activity was discovered by serendipity. In the meantime
[Flupirtin (katadolon): a nonstandard action on pain transmission].
V V Alekseev
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 111(4), 101-104 (2011-09-09)
Joint Diseases: New Insights for the Healthcare Professional, 13-13 (2013)
[Chronic backache. Rational therapy of muscle-induced pain].
MMW Fortschritte der Medizin, 154(3), 86-87 (2012-03-31)
Karthikeyan Kandasamy et al.
Arzneimittel-Forschung, 61(12), 693-699 (2012-01-28)
A simple, highly sensitive, precise and accurate high-performance liquid chromatographic (LCMSMS) method with mass detection was developed and validated for the rapid quantification of flupirtine (CAS 75507-68-5) in rat plasma samples. The chromatographic separation was achieved with a reverse phase
View All Related Papers

Related Content

Data Sheet - F8927

Instructions

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service