M5760

4-(4-Methoxybenzylamino)-7-nitrobenzofurazan

Name: 4-(4-Methoxybenzylamino)-7-nitrobenzofurazan
Brand: SIGMA

>97.5% purity (HPLC), powder

Synonym(s):

4-(4-Methoxybenzylamino)-7-nitro-2,1,3-benzoxadiazole, MBD

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₂N₄O₄

CAS Number:

33984-50-8

Molecular Weight:

300.27

NACRES:

NA.47

PubChem Substance ID:

24897041

UNSPSC Code:

12171500

EC Number:

251-775-9

MDL number:

MFCD00042778

Beilstein/REAXYS Number:

1151390

Product Name

4-(4-Methoxybenzylamino)-7-nitrobenzofurazan,

InChI key

IENONFJSMWUIQQ-UHFFFAOYSA-N

InChI

1S/C14H12N4O4/c1-21-10-4-2-9(3-5-10)8-15-11-6-7-12(18(19)20)14-13(11)16-22-17-14/h2-7,15H,8H2,1H3

SMILES string

COc1ccc(CNc2ccc([N+]([O-])=O)c3nonc23)cc1

assay

>97.5% (HPLC)

form

powder

color

orange to red

solubility

DMSO:methanol (1:1): 50 mg/mL, clear, orange

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

−20°C

Quality Level

100

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Application

Fluorescent probe for hydrophobic (non-polar) regions in proteins and nucleoproteins.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Structural analyses reveal that MBD3 is a methylated CG binder.

Ke Liu et al.

The FEBS journal, 286(16), 3240-3254 (2019-04-14)

The MBD3, a methyl-CpG-binding domain (MBD)-containing protein, is a core subunit of the Mi-2/NuRD complex. Recent reports show that MBD3 recognizes both methylated CG (mCG)- and hydroxymethylated CG (hmCG)-containing DNA, with a preference for hmCG. However, whether the MBD3-MBD indeed

Optical intrinsic signal imaging with optogenetics reveals functional cortico-cortical connectivity at the columnar level in living macaques.

Yu Nakamichi et al.

Scientific reports, 9(1), 6466-6466 (2019-04-25)

Despite extensive research on primate cognitive function, understanding how anatomical connectivity at a neural circuit level relates to information transformation across different cortical areas remains primitive. New technology is needed to visualize inter-areal anatomical connectivity in living monkeys and to

Complete Profiling of Methyl-CpG-Binding Domains for Combinations of Cytosine Modifications at CpG Dinucleotides Reveals Differential Read-out in Normal and Rett-Associated States.

Benjamin C Buchmuller et al.

Scientific reports, 10(1), 4053-4053 (2020-03-07)

5-Methylcytosine (mC) exists in CpG dinucleotides of mammalian DNA and plays key roles in chromatin regulation during development and disease. As a main regulatory pathway, fully methylated CpG are recognized by methyl-CpG-binding domain (MBD) proteins that act in concert with

Bismuth classification is associated with the requirement for multiple biliary drainage in preoperative patients with malignant perihilar biliary stricture.

Shin Miura et al.

Surgical endoscopy, 29(7), 1862-1870 (2014-10-04)

Single preoperative biliary drainage for malignant perihilar biliary stricture occasionally fails to control jaundice and cholangitis. Multiple biliary drainage is required in such cases, but their clinical background is unclear. We determined the clinical characteristics associated with the requirement for

Comparison of Intact Parathyroid Hormone, Alkaline Phosphatase, Phosphate Levels for Diagnosing Severe Metabolic Bone Disease in Infants with Severe Bronchopulmonary Dysplasia.

Erin K Tkach et al.

American journal of perinatology, 34(12), 1199-1204 (2017-04-22)

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