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Merck

M6524

Methoxamine hydrochloride

α1-adrenoceptor agonist

Synonym(s):

α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H17NO3 · HCl
CAS Number:
61-16-5
Molecular Weight:
247.72
NACRES:
NA.77
PubChem Substance ID:
24277785
UNSPSC Code:
12352116
EC Number:
200-499-7
MDL number:
MFCD00058607
Quality level:
200

Key Documents

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Product Name

Methoxamine hydrochloride,

Quality Level

200

InChI key

YGRFXPCHZBRUKP-UHFFFAOYSA-N

InChI

1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H

SMILES string

Cl[H].COc1ccc(OC)c(c1)C(O)C(C)N

storage temp.

2-8°C

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Related Categories

Biochem/physiol Actions

α1-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000526209
0000526209
0000515863
0000515863
0000434852

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R H Lee et al.
Journal of neurophysiology, 81(5), 2164-2174 (1999-05-13)
Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. Like many types of motoneurons, spinal motoneurons in the adult mammal can exhibit bistable behavior. This means that short periods of excitatory input can initiate long
ShiYong Huang et al.
Neuron, 73(3), 497-510 (2012-02-14)
Neuromodulatory input, acting on G protein-coupled receptors, is essential for the induction of experience-dependent cortical plasticity. Here we report that G-coupled receptors in layer II/III of visual cortex control the polarity of synaptic plasticity through a pull-push regulation of LTP
Lindsay D MacKenzie et al.
The journal of sexual medicine, 8(9), 2461-2471 (2011-06-29)
Mean arterial pressure (MAP) and specific regulation of penile blood flow are the primary determinants of an erection. While this concept is well recognized, the differential relationship between systemically acting vasoactive factors on arterial pressure and erectile responses is not
Robert H Thiele et al.
Anesthesia and analgesia, 113(2), 284-296 (2011-04-27)
Phenylephrine and methoxamine are direct-acting, predominantly α(1) adrenergic receptor (AR) agonists. To better understand their physiologic effects, we screened 463 articles on the basis of PubMed searches of "methoxamine" and "phenylephrine" (limited to human, randomized studies published in English), as
Alain Frigon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(15), 5579-5588 (2011-04-15)
Extra forces or torques are defined as forces or torques that are larger than would be expected from the input or stimuli, which can be mediated by properties intrinsic to motoneurons and/or to the muscle. The purpose of this study
View All Related Papers

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