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Merck

SML0021

PDI inhibitor 16F16

≥98% (HPLC)

Synonym(s):

2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester, Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C16H17ClN2O3
CAS Number:
922507-80-0
Molecular Weight:
320.77
NACRES:
NA.77
PubChem Substance ID:
329825093
UNSPSC Code:
12352200
MDL number:
MFCD20134198

Product Name

PDI inhibitor 16F16, ≥98% (HPLC)

InChI key

BCSIRYFYAKLJDK-UHFFFAOYSA-N

SMILES string

COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl

InChI

1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: 12 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

PDI inhibitor 16F16 has been used to inhibit PDI (protein disulfide isomerase) function to examine the functional conservation of PDIs in human embryonic kidney cells.
PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.

Biochem/physiol Actions

16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.
Protein disulfide isomerase (PDI) inhibitor; suppresses apoptosis induced by misfolded proteins

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000503283
0000503280
0000503280
0000503283
0000407222

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A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion
Torpe N, et al.
Cell Reports, 26(12), 3183-3190 (2019)
Nanna Torpe et al.
Cell reports, 26(12), 3183-3190 (2019-03-21)
Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for secretion, proteins that directly mediate Wnt folding and maturation remain uncharacterized. Here, we report that protein disulfide isomerase-1 (PDI-1), a protein-folding
Ying Yuan et al.
Materials today. Bio, 21, 100697-100697 (2023-06-22)
Anastomotic thrombosis prevalently causes anastomosis failure, accompanied with ischemia and necrosis, the early diagnosis of which is restricted by inherent shortcomings of traditional imaging techniques in clinic and lack of appropriate prodromal biomarkers for thrombosis initiation. Herein, a fresh thrombus-specific
Nayeli Aguilar-Hernández et al.
Viruses, 13(1) (2021-01-06)
Although human astroviruses (HAstVs) are important agents of gastroenteritis in young children, the studies aimed at characterizing their biology have been limited, in particular regarding their cell entry process. It has been shown that HAstV serotype 8 enters human cells
Yuanyuan Yan et al.
Cell death and differentiation, 29(9), 1769-1789 (2022-03-19)
Hypoxic tumor microenvironment (TME) plays critical roles in induction of cancer stem cell-like phenotype in breast cancer and contribute to chemoresistance. However, the mechanism underlying stemness reprogramming of breast cancer cells (BCs) by hypoxic TME remains largely unknown. In the
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