SML0440
Spautin-1
≥98% (HPLC), Autophagy inhibitor, powder
Synonym(s):
6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine, C43
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C15H11F2N3
CAS Number:
Molecular Weight:
271.26
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Spautin-1, ≥98% (HPLC)
SMILES string
FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
InChI
1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChI key
AWIVHRPYFSSVOG-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL (clear solution)
storage temp.
2-8°C
Quality Level
Related Categories
Application
Spautin-1 has been used as an autophagy inhibitor:
- to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model
- to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin
- to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay
Biochem/physiol Actions
Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.
Spautin-1 is an inhibitor of autophagy.
Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Alice Verchère et al.
Scientific reports, 2, 306-306 (2012-03-09)
We describe an original activity assay for membrane transport that uses the proton motive force-dependent efflux pump MexAB from Pseudomonas aeruginosa. This pump is co-reconstituted into proteoliposomes together with bacteriorhodopsin (BR), a light-activated proton pump. In this system, upon illumination
Daniel G Panaccione et al.
Scientific reports, 7(1), 8930-8930 (2017-08-23)
Neosartorya fumigata (Aspergillus fumigatus) is the most common cause of invasive aspergillosis, a frequently fatal lung disease primarily affecting immunocompromised individuals. This opportunistic fungal pathogen produces several classes of specialised metabolites including products of a branch of the ergot alkaloid
Leonhard H Urner et al.
Nature communications, 11(1), 564-564 (2020-01-30)
Detergents enable the purification of membrane proteins and are indispensable reagents in structural biology. Even though a large variety of detergents have been developed in the last century, the challenge remains to identify guidelines that allow fine-tuning of detergents for
Z Solhjou et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 17(9), 2326-2337 (2017-03-16)
Ischemia-reperfusion injury (IRI) evokes intragraft inflammatory responses, which markedly augment alloimmune responses against the graft. Understanding the mechanisms underlying these responses is fundamental to develop therapeutic regimens to prevent/ameliorate organ IRI. Here, we demonstrate that IRI results in a marked
Heng Ning Wu et al.
PloS one, 13(10), e0205328-e0205328 (2018-10-17)
Ureaplasma parvum serovar 3 strain, OMC-P162, was isolated from the human placenta of a preterm delivery at 26 weeks' gestation. In this study, we sequenced the complete genome of OMC-P162 and compared it with other serovar 3 strains isolated from
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service