Product Name
AM1710, ≥97% (HPLC), powder, CB2 agonist
Quality Level
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
AM1710 is a highly potent and selective CB2 agonist that displays 54-fold selectivity for CB2 over CB1. AM1710 is a low potency inverse agonist/antagonist at CB1 in vitro but is not a functional CB1 antagonist in vivo. It inhibits chemotherapy-induced neuropathic pain in rodents while delaying the development of morphine tolerance and reduced naloxone-precipitated opioid withdrawal.
Application
AM1710 may be used to study the effects of CB2 agonists on neuropathic nociception induced by the antiretroviral agent Zalcitabine, in a mouse model.
General description
AM1710, a CB2 agonist, belongs to the class of cannabinoids known as cannabilactones. Cannabilactones are characterized by the presence of a carbonyl group instead of the 6,6-dimethyl group typically found in the classical tricyclic structure of cannabinoids.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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