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Merck

SML4251

AM1710

≥97% (HPLC)

Synonym(s):

3-(1,1-Dimethylheptyl)-1-hydroxy-9-methoxy-6H-dibenzo[b,d]pyran-6-one, AM 1710

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About This Item

Empirical Formula (Hill Notation):
C23H28O4
CAS Number:
335371-36-3
Molecular Weight:
368.47
UNSPSC Code:
12352200

Product Name

AM1710, ≥97% (HPLC)

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

AM1710 is a highly potent and selective CB2 agonist that displays 54-fold selectivity for CB2 over CB1. AM1710 is a low potency inverse agonist/antagonist at CB1 in vitro but is not a functional CB1 antagonist in vivo. It inhibits chemotherapy-induced neuropathic pain in rodents while delaying the development of morphine tolerance and reduced naloxone-precipitated opioid withdrawal.

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