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Merck

208724

Calpain Inhibitor IV

The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Calpain Inhibitor IV, Z-LLY-FMK

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About This Item

Empirical Formula (Hill Notation):
C30H40FN3O6
Molecular Weight:
557.65
NACRES:
NA.77
UNSPSC Code:
12352200

Product Name

Calpain Inhibitor IV, The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white to pale yellow

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

General description

A potent, cell-permeable and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).
A potent, cell-permeable, and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Analysis Note

single spot by TLC

Biochem/physiol Actions

Cell permeable: yes
Primary Target
calpain 2
Product does not compete with ATP.
Reversible: no
k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L

Other Notes

Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.
Z-Leu-Leu-Tyr-CH₂F

Disclaimer

Toxicity: Standard Handling (A)

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kirill Gorshkov et al.
ACS infectious diseases, 7(6), 1389-1408 (2020-12-22)
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Vimala Bondada et al.
Biochimica et biophysica acta. Molecular cell research, 1868(7), 119019-119019 (2021-04-04)
The enzymatic characteristics of the ubiquitous calpain 5 (CAPN5) remain undescribed despite its high expression in the central nervous system and links to eye development and disease. CAPN5 contains the typical protease core domains but lacks the C terminal penta-EF
Anna Luganini et al.
mBio, 14(4), e0074923-e0074923 (2023-07-21)
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