Skip to Content
Merck

Key Documents

View All Documentation

648311

Tris Base

≥99% dry basis (titration), crystalline solid, pH 10.3-11.3, Ultrol® Grade

Synonym(s):

Tris(hydroxymethyl)aminomethane, tris(Hydroxymethyl)aminomethane, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Linear Formula:
NH2C(CH2OH)3
CAS Number:
77-86-1
Molecular Weight:
121.14
UNSPSC Code:
12161705
NACRES:
NA.25
MDL number:
MFCD00004679
Beilstein/REAXYS Number:
741883
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Tris Base, ULTROL® Grade, ≥99% dry basis (titration), useful in pH range 10.3-11.3

description

Merck USA index - 14, 9772

Quality Level

100

assay

≥99% dry basis (titration)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

useful pH range

7-9

pKa (25 °C)

8.1

bp

219-220 °C/10 mmHg (lit.)

mp

167-172 °C (lit.)

solubility

water: 1 M

cation traces

heavy metals: ≤5 ppm

shipped in

ambient

storage temp.

10-30°C

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

General description

Absorbance (1.0 M, H2O, 260 nm): <0.05.
Useful in the pH range of 10.3-11.3. Has a pKa of 8.1 at 25°C.
Widely used as a biological buffer (absorbance: <0.05 at 260 nm, 1.0 M, H2O). A 1.0 M solution in H2O has a pH range of 10.3-11.3 and a pKa of 8.3 at 20°C.

Application


  • Development of an Antigen Capture Lateral Flow Immunoassay for the Detection of Burkholderia pseudomallei.: This study uses Tris Base in the development of a lateral flow immunoassay for detecting Burkholderia pseudomallei, enhancing diagnostic capabilities in clinical microbiology (Nualnoi et al., 2024).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Still not finding the right product?

Explore all of our products under Tris Base

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Aura E Ionescu et al.
International journal of molecular sciences, 20(24) (2019-12-19)
Eyes absent (EYA) are non-thiol-based protein tyrosine phosphatases (PTPs) that also have transcriptional co-activator functions. Their PTP activity is involved in various pathologies. Recently, we demonstrated that Src tyrosine kinase phosphorylates human EYA3 by controlling its subcellular localization. We also