L3265
Lipoteichoic acid from Bacillus subtilis
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About This Item
biological source
Bacillus subtilis
Quality Level
form
lyophilized powder
lipid type
polymerizable lipids
shipped in
ambient
storage temp.
2-8°C
Biochem/physiol Actions
Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of gram-positive bacteria. Lipoteichoic acid from Bacillus subtilis may be used to compare its structure, immunogenicity and functions versus other bacterial LTAs.
Lipoteichoic acid (LTA) is a teichoic acid attached to a lipid abundant on Gram-positive bacteria cell wall. LTA is a pathogen-associated molecular-patterns (PAMP) recognized by Toll-like receptor 2 (TLR2), This recognition leads to the activation of NF-kB.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Mardi A Crane-Godreau et al.
Infection and immunity, 73(1), 476-484 (2004-12-25)
Having previously shown that CCL20/macrophage inflammatory protein 3alpha and tumor necrosis factor alpha (TNF-alpha) are released by polarized primary rat uterine epithelial cells (UEC) in response to Escherichia coli but not to Lactobacillus rhamnosus, we sought to determine if epithelial
Intrinsic nitric oxide-stimulatory activity of lipoteichoic acids from different Gram-positive bacteria.
Zidek Z, Farghali H, Kmonickova E.
Nitric Oxide, 232, 300-310 (2010)
Young Hee Ryu et al.
International immunopharmacology, 9(1), 127-133 (2008-11-18)
Lipoteichoic acid (LTA) is a major immunostimulating component in the cell wall of Gram-positive bacteria as lipopolysaccharide of Gram-negative bacteria. However, LTA is expressed on not only pathogenic but also nonpathogenic Gram-positive bacteria. In order to examine whether the immunostimulating