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Merck

SBR00122

Streptozocin

Ready Made Solution, 20 mg/mL (in citrate buffer (pH=4.5))

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About This Item

Empirical Formula (Hill Notation):
C8H15N3O7
Molecular Weight:
265.22
UNSPSC Code:
51101500
NACRES:
NA.21

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InChI

InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

SMILES string

CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O

biological source

synthetic

assay

≥97% (HPLC)

form

liquid, ready-to-use solution

storage condition

(Light Sensitive)

concentration

20 mg/mL (in citrate buffer (pH=4.5))

color

colorless to yellow

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

General description

Streptozocin (STZ) found to have two anomers, α and β. STZ is a methylnitrosourea that attached to a glucosamine molecule. As nitrosourea class alkylating agent it results with toxic effect to the cells and cause damage to the DNA.

Application

Streptozocin has been used -
  • As an antibiotic4 and antineoplastic agent.
  • As a toxic to insulin producing β-cells of pancreas in mammals The relative toxicity to β-cells is occurring because of the similarity of STZ to glucose, as it transported into the cells by glucose transport protein, GLUT2, which is highly expressed on β-cells.
  • For treating cancer of Islets of Langerhans and to produce animal models of type 1, diabetes.
  • To induce diabetes in rats.It is injected at 60-100mg/Kg to induce diabetes in rats model.

Biochem/physiol Actions

Mode of Action: Streptozocin is an N-nitroso-containing compound which acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes.

Antimicrobial Spectrum: Active against a broad spectrum antibiotic activity and antineoplastic properties.

Features and Benefits

High quality antibiotic suitable for mulitple research applications

Preparation Note

The solution is light-sensitive and should be used immediately after thawing. Thaw at room temperature; avoid heating.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H341,H351

Hazard Classifications

Carc. 2 - Muta. 2

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000459211
0000459211

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