440191
Hexamethyldisilazane
reagent grade, ≥99%
Synonym(s):
Bis(trimethylsilyl)amine, HMDS
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About This Item
Linear Formula:
(CH3)3SiNHSi(CH3)3
CAS Number:
Molecular Weight:
161.39
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
EC Number:
213-668-5
Beilstein/REAXYS Number:
635752
MDL number:
Product Name
Hexamethyldisilazane, reagent grade, ≥99%
InChI key
FFUAGWLWBBFQJT-UHFFFAOYSA-N
InChI
1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3
SMILES string
C[Si](C)(C)N[Si](C)(C)C
grade
reagent grade
assay
≥99%
form
liquid
refractive index
n20/D 1.407 (lit.)
bp
125 °C (lit.)
Quality Level
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Application
Hexamethyldisilane (HMDS) can be used:
- As a silylating agent in the trimethylsilylation of alcohols under nearly neutral reaction conditions.
- To control the molecular weights of polypeptides during ring-opening polymerization of α-amino acid N-carboxyanhydrides.
- To fabricate silicon carbonitride thin films by plasma-enhanced CVD.
- For specimen preparation for scanning electron microscopy and the preparation of trimethylsilyl ethers from hydroxy compounds.
Features and Benefits
- High chemicalstability and low molecular weight
- Nontoxic andcost-effective reagent
- Ammonia is theonly byproduct generated during silylation
- Silylationreaction using HDMS is nearly neutral and does not need any precaution
General description
Hexamethyldisilane (HMDS) is a stable and effectivereagent for trimethylsilylation of hydrogen-labile substrates such as alcohols,amines, and carboxylic acids. It is commonly used for the protection of sensitivefunctional groups during chemical synthesis. Owing to its low cost, high vapor pressure, and safety, itis widely used as a precursor in chemical vapor deposition(CVD) reactions.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2
Storage Class
3 - Flammable liquids
wgk
WGK 2
flash_point_f
52.5 °F - closed cup
flash_point_c
11.4 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Rapid and highly efficient trimethylsilylation of alcohols and phenols
with hexamethyldisilazane (HMDS) catalysed by in situ generated I2
using OxoneR /KI or cerium ammonium nitrate (CAN)/KI systems
under mild conditions
with hexamethyldisilazane (HMDS) catalysed by in situ generated I2
using OxoneR /KI or cerium ammonium nitrate (CAN)/KI systems
under mild conditions
Eskandar K, et al.
Journal of Chemical Sciences (Bangalore), 123(5), 703-708 (2011)
F Braet et al.
Journal of microscopy, 186(Pt 1), 84-87 (1997-04-01)
Critical point drying (CPD) is a common method of drying biological specimens for scanning electron microscopy (SEM). Drying by evaporation of hexamethyldisilazane (HMDS) has been described as a good alternative. This method, however, is infrequently used. Therefore, we reassessed HMDS
Judith J de Vries et al.
International journal of molecular sciences, 21(19) (2020-10-01)
Subjects with diabetes mellitus (DM) have an increased risk of arterial thrombosis, to which changes in clot structure and mechanics may contribute. Another contributing factor might be an increased formation of neutrophil extracellular traps (NETs) in DM. NETs are mainly
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Apical projections are integral functional units of epithelial cells. Microvilli and stereocilia are cylindrical apical projections that are formed of bundled actin. Microridges on the other hand, extend laterally, forming labyrinthine patterns on surfaces of various kinds of squamous epithelial
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