856525
2-Methyl-1,2-di-3-pyridyl-1-propanone
96%
Synonym(s):
Metyrapone, Su-4885
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About This Item
Empirical Formula (Hill Notation):
C14H14N2O
CAS Number:
Molecular Weight:
226.27
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-206-2
Beilstein/REAXYS Number:
163023
MDL number:
Assay:
96%
Form:
powder
Quality Level
assay
96%
form
powder
mp
52-55 °C (lit.)
functional group
ketone
SMILES string
CC(C)(c1cccnc1)C(=O)c2cccnc2
InChI
1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3
InChI key
FJLBFSROUSIWMA-UHFFFAOYSA-N
Application
2-Methyl-1,2-di-3-pyridyl-1-propanone inhibits the biosynthesis of corticosterone by blocking the conversion of deoxycorticosterone to corticosterone. It is widely used in adrenocortical-related clinical studies.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Screening for modulatory effects on steroidogenesis using the human H295R adrenocortical cell line: a metabolomics approach.
Rijk JCW, et al.
Chemical Research in Toxicology, 25(8), 1720-1731 (2012)
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Soleimani AF, et al.
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 161(2), 140-144 (2012)
Laia Ribas et al.
The Journal of experimental biology, 220(Pt 6), 1056-1064 (2017-01-14)
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