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About This Item
Linear Formula:
NH2CH2COOCH3 · HCl
CAS Number:
Molecular Weight:
125.55
NACRES:
NA.22
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
227-139-1
MDL number:
Beilstein/REAXYS Number:
3593644
Product Name
Glycine methyl ester hydrochloride, 99%
InChI key
COQRGFWWJBEXRC-UHFFFAOYSA-N
InChI
1S/C3H7NO2.ClH/c1-6-3(5)2-4;/h2,4H2,1H3;1H
SMILES string
Cl.COC(=O)CN
assay
99%
form
powder, crystals or chunks
reaction suitability
reaction type: solution phase peptide synthesis
color
white
mp
175 °C (dec.) (lit.)
application(s)
peptide synthesis
Quality Level
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Application
Glycine methyl ester hydrochloride is used to synthesize cyclophosphazene compounds with amino acid esters as side groups. Additionally, it can be utilized to synthesize peptides in aqueous medium, which makes it a green method for peptide formation.
General description
Glycine methyl ester hydrochloride, also known as methyl glycinate hydrochloride, is a derivative of glycine, used in the preparation of amino acids and organic compounds.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The investigation of thermosensitive properties of phosphazene derivatives bearing amino acid ester groups
A Uslu
Journal of Molecular Structure, 1136, 90-99 (2017)
A green protocol for peptide bond formation in WEB
M Konwar
Tetrahedron Letters, 57, 2283-2285 (2016)
K W Kuo et al.
International journal of peptide and protein research, 46(2), 181-185 (1995-08-01)
To study the functional involvements of the common interaction of the Leu-1 alpha-amino group and Asp-58 in cobrotoxin, the lysine epsilon-amino groups of cobrotoxin were initially guanidinated with o-methylisourea. The alpha-amino group of Leu-1 was them modified with TNBS after
D Levy
Biochimica et biophysica acta, 317(2), 473-481 (1973-08-30)
A procedure has been described for the modification of the amino group of glycine methyl ester, and the amino groups of the hormone, insulin, with the reagent p-nitrophenyl-p-chloromercuribenzoate, effecting the introduction of the chloromercuri group at various defined sites in
L K Frankel et al.
Biochemistry, 38(43), 14271-14278 (1999-11-26)
The effects of the modification of carboxylate groups on the manganese-stabilizing protein of photosystem II were investigated. Carboxylate groups (including possibly the C-terminus) on the manganese-stabilizing protein were modified with glycine methyl ester in a reaction facilitated by 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide. The
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