H1384
Hypotaurine
≥98% (TLC)
Synonym(s):
2-Aminoethanesulfinic acid
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About This Item
Empirical Formula (Hill Notation):
C2H7NO2S
CAS Number:
Molecular Weight:
109.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Product Name
Hypotaurine, ≥98% (TLC)
InChI
1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
SMILES string
NCCS(O)=O
InChI key
VVIUBCNYACGLLV-UHFFFAOYSA-N
assay
≥98% (TLC)
color
white to off-white
solubility
H2O: 100 mg/mL
Quality Level
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Related Categories
Application
Hypotaurine has been used as a supplement in fertilization medium (Fert- tyrode albumin lactate pyruvate (TALP)), which used in in-vitro fertilization and evaluation of embryo development. It is also used as a H2S scavenger.
Biochem/physiol Actions
Antioxidant that binds hydroxyl radicals. Endogenous inhibitory neuromodulator that is blocked by strychnine and picrotoxin. Inhibits the Na2+-dependent transport of GABA and β-alanine. It is a degradation product of cysteine and a precursor of taurine.
Hypotaurine, a cystamine analog, is the precursor for taurine synthesis. It can act as an antioxidant and singlet oxygen scavenger, thereby protecting cells from oxidative damage. Hypotaurine is reported to play an important role in the maintenance and stimulation of sperm motility and also in vitro fertilization and embryo development.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The Significance of hydrogen sulfide for Arabidopsis seed germination.
Baudouin E, et al.
Frontiers in Plant Science, 7, 930-930 (2016)
Protective effect of hypotaurine against oxidative stress-induced cytotoxicity in rat placental trophoblasts.
Nishimura T
Placenta, 36(6), 693-698 (2015)
M M Mahadevan et al.
Fertility and sterility, 43(2), 263-267 (1985-02-01)
Removal of cumulus may increase the chance of fertilization in patients with sperm antibodies, may facilitate fertilization in vitro with a small number of spermatozoa, and is necessary for microsurgical injection procedures in vitro. The aim of this study was
Andrea Carenzo et al.
Cells, 9(8) (2020-08-07)
Oral premalignant lesions (OPLs) represent the most common oral precancerous conditions. One of the major challenges in this field is the identification of OPLs at higher risk for oral squamous cell cancer (OSCC) development, by discovering molecular pathways deregulated in
Ultrastructural and immunohistochemical characterization of the bovine epiblast.
Vejlsted M, et al.
Biology of Reproduction, 72(3), 678-686 (2005)
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