N8141
4-Nitroquinoline N-oxide
≥98%
Synonym(s):
4-NQO, 4-Nitroquinoline 1-oxide
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About This Item
Empirical Formula (Hill Notation):
C9H6N2O3
CAS Number:
Molecular Weight:
190.16
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-281-1
Beilstein/REAXYS Number:
165756
MDL number:
Assay:
≥98%
InChI key
YHQDZJICGQWFHK-UHFFFAOYSA-N
InChI
1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H
SMILES string
[O-][N+](=O)c1cc[n+]([O-])c2ccccc12
assay
≥98%
color
yellow to brown
mp
154-156 °C (lit.)
solubility
acetone: soluble, clear to hazy
storage temp.
−20°C
Related Categories
General description
4-Nitroquinoline N-oxide is a quinoline derivative widely used in chemical research and development.
Application
4-Nitroquinoline N-oxide has been used as a model compound to study its carcinogenic effects.
Biochem/physiol Actions
Skin and lung tumor initiator under experimental conditions.
signalword
Danger
hcodes
Hazard Classifications
Carc. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
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Ye Du et al.
Environment international, 135, 105369-105369 (2019-12-17)
Effluents from wastewater treatment plants (WWTPs) may contain various pollutants with potential toxic effects. Ozonation is widely applied to purify wastewater, which may influence the toxicity and water quality indices simultaneously. The main goal of this study was to reveal
Interplay of DNA repair, homologous recombination, and DNA polymerases in resistance to the DNA damaging agent 4-nitroquinoline-1-oxide in Escherichia coli.
Williams AB, et al.
DNA Repair, 9(10), 1090-1097 (2010)
Antitumor activity of ficus deltoidea extract on oral cancer: An in vivo study
Al-Koshab M, et al.
Journal of Oncology, 2020 (2020)
The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO-and t-BOOH-induced mutagenesis in coli.
Nikolic B, et al.
Archives of Biological Sciences, 63(1), 117-128 (2011)
Ting-Hui Chu et al.
Cancer letters, 337(1), 115-124 (2013-06-04)
miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFβRII with the miR-211-TGFβRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211
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