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Merck

A9199

2-Amino-2-methyl-1-propanol

BioXtra, ≥95%

Synonym(s):

β-Aminoisobutyl alcohol, AMP

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About This Item

Linear Formula:
(CH3)2C(NH2)CH2OH
CAS Number:
Molecular Weight:
89.14
UNSPSC Code:
12161700
NACRES:
NA.25
PubChem Substance ID:
EC Number:
204-709-8
Beilstein/REAXYS Number:
505979
MDL number:

Product Name

2-Amino-2-methyl-1-propanol, BioXtra, ≥95%

InChI

1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3

InChI key

CBTVGIZVANVGBH-UHFFFAOYSA-N

SMILES string

CC(C)(N)CO

vapor density

3 (vs air)

vapor pressure

<1 mmHg ( 25 °C)

product line

BioXtra

assay

≥95%

form

liquid

impurities

≤0.005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

refractive index

n20/D 1.4455 (lit.)

pH

11.0-12 (25 °C, 8.9 g/L)

useful pH range

9.0-10.5

pKa (25 °C)

9.7

bp

165 °C (lit.)

mp

24-28 °C (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

0.934 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

Quality Level

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Application

2-Amino-2-methyl-1-propanol has been used as an component in enzyme assay for screening the alkaline phosphatase activity in sarcoma osteogenic (SaOS-2) cells..

Biochem/physiol Actions

2-Amino-2-methyl-1-propanol is a substituted aliphatic alcohol and is used majorly as a pH balancer in cosmetic formulations. It has phototoxic effect as it can interact and penetrate above the sebum layer. However, it is not carcinogenic.

pictograms

Corrosion

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

179.8 °F - closed cup

flash_point_c

82.1 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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The morphogenetically active polymer, inorganic polyphosphate complexed with GdCl3, as an inducer of hydroxyapatite formation in vitro
Wang X, et al.
Biochemical Pharmacology, 102(6), 97-106 (2016)
Final amended report on safety assessment on aminomethyl propanol and aminomethyl propanediol
Burnett CL, et al.
International Journal of Toxicology, 28(6), 141S-161S (2009)
Phototoxic assessment of a sunscreen formulation and its excipients: An in vivo and in vitro study
Hossy BH, et al.
Journal of Photochemistry and Photobiology. B, Biology, 173(6), 545-550 (2017)
Sontaya Limmatvapirat et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 67(3), 690-698 (2007-06-20)
The objective of this study was to improve the properties of shellac by composite salts formation. The shellac samples were prepared in various salt forms by dissolving them with 2-amino-2-methyl-1-propanol (AMP) and ammonium hydroxide (AMN) at various ratios of AMP:AMN.
R A Stinson
Clinical chemistry, 39(11 Pt 1), 2293-2297 (1993-11-01)
Nine different isoenzymes and (or) isoforms of alkaline phosphatase (ALP; EC 3.1.3.1) from human tissue were studied with respect to Km and Vmax values for p-nitrophenyl phosphate (p-NPP) in seven different potential phosphoacceptors/buffers. Generally, the phosphoacceptors/buffers with the lowest affinity

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