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About This Item
Empirical Formula (Hill Notation):
C11H11N3O2S
CAS Number:
Molecular Weight:
249.29
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
205-642-7
Beilstein/REAXYS Number:
222065
MDL number:
Quality Level
assay
≥99.0%
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
Nc1ccc(cc1)S(=O)(=O)Nc2ccccn2
InChI
1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)
InChI key
GECHUMIMRBOMGK-UHFFFAOYSA-N
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General description
Sulfapyridine is a metabolite of Sulfasalazine. It is an antibiotic and is mostly used in treating rheumatoid arthritis.
Application
Sulfapyridine may be used as a reference standard in the determination of sulfapyridine in milk samples and plasma samples, using electrochemical magneto immunosensing assay technique and high performance liquid chromatography (HPLC), respectively.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Warning
hcodes
Hazard Classifications
Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 2
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Determination of sulfapyridine and its major metabolites in plasma by high-pressure liquid chromatography.
Fischer C and Klotz U.
Journal of Chromatography. B, Biomedical Sciences and Applications, 146(1), 157-162 (1978)
Electrochemical magneto immunosensing of antibiotic residues in milk.
Zacco E, et al.
Biosensors And Bioelectronics, 22(9-10), 2184-2191 (2007)
Christopher Chidley et al.
Nature chemical biology, 7(6), 375-383 (2011-04-19)
We introduce an approach for detection of drug-protein interactions that combines a new yeast three-hybrid screening for identification of interactions with affinity chromatography for their unambiguous validation. We applied the methodology to the profiling of clinically approved drugs, resulting in
Cemalettin Alp et al.
Journal of enzyme inhibition and medicinal chemistry, 27(6), 818-824 (2011-12-23)
The inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I, II and human serum isozyme VI, with a series of tosylited aromatic amine derivatives was investigated. The K(I) ranges of compounds 1-14 and acetazolamide against hCA I
Amirali Popat et al.
Angewandte Chemie (International ed. in English), 51(50), 12486-12489 (2012-11-07)
I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are
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