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Merck

07076

Castor Oil, Hydrogenated,Ethoxylated

Synonym(s):

Cremophor® RH 40, Macrogolglycerol hydroxystearate, PEG-40 castor oil, Polyoxyl 40 hydrogenated castor oil, RH 40

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About This Item

CAS Number:
61788-85-0
UNSPSC Code:
12161900
NACRES:
NA.25
MDL number:
MFCD01771439

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Quality Level

100

impurities

≤0.2% sulfated ash (verfied on random samples only), ≤1 ppm ethylene oxide, ≤10 ppm dioxan, ≤10 ppm heavy metals (verfied on random samples only), ≤2 ppm arsenic (verfied on random samples only), ≤2.0% water, ≤5000 ppm acetic acid, ≤620 ppm diethylene glycol, ≤620 ppm ethylene glycol

ign. residue

≤0.25% (verfied onrandom samples only)

acid value

≤0.8 mg KOH/g

hydroxyl value

60‑75 mg KOH/g

iodine value

≤1.0 g I2/100 g

saponification value

50‑60 mg KOH/g

suitability

suitable for acidity or alkalinity

Related Categories

Application

Castor Oil, Hydrogenated,Ethoxylated is used to solubilize vitamins, water insoluble active substances and essential oils in water or mixtures of water and alcohol.

Analysis Note

congealing temperature 16-26°C

Other Notes

Castor Oil, Hydrogenated, Ethoxylated is the brand name for a range of non-ionic polyethoxylated detergents. It was developed for use as solubilizers and emulsifiers.

Legal Information

Cremophor is a registered trademark of BASF SE

Storage Class

11 - Combustible Solids

flash_point_f

467.6 °F

flash_point_c

242 °C

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6035
BCCM7386
BCCL5058
BCCL5059
BCCM3260

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Christofori M R R Nastiti et al.
Pharmaceutics, 12(2) (2020-02-06)
Resveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant. Nanoformulations were prepared using a spontaneous emulsification method, and
Jong Soo Woo et al.
Archives of pharmacal research, 30(1), 82-89 (2007-03-03)
Silymarin has been used to treat hepatobiliary diseases. However, it has a low bioavailability after being administered orally on account of its low solubility in water. In order to improve the dissolution rate, silymarin was formulated in the form of
Hideki Ichikawa et al.
Current drug delivery, 4(2), 131-140 (2007-04-26)
The effects of the formulation and particle composition of gadolinium (Gd)-containing lipid nanoemulsion (Gd-nanoLE) on the biodistribution of Gd after its intravenous (IV) injection in D(1)-179 melanoma-bearing hamsters were evaluated for its application in cancer neutron-capture therapy. Gd-nanoLEs whose particles
Ravouru Nagaraju et al.
Current drug discovery technologies, 6(4), 299-305 (2009-12-23)
The core-in-cup matrix tablets of Metoprolol succinate were prepared by wet granulation technique. Of all the investigated formulations, the optimized formulation of MS-09 followed zero-order kinetics of drug release. Trail on MS-09 was formulated using 7.5% hydrogenated castor-oil (HCO) and
Enas A Mahmoud et al.
AAPS PharmSciTech, 10(1), 183-192 (2009-02-25)
The purpose of this study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form emphasizing the excipients' effect on the development of a new dosage form. Systems composed of HCO-40, Transcutol HP
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