A5282
DL-2-Amino-5-phosphonopentanoic acid
≥98% (TLC), solid, NMDA receptor antagonist
Synonym(s):
5-Phosphono-DL-norvaline, DL-2-Amino-5-phosphonovaleric acid, AP-5, APV
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About This Item
Empirical Formula (Hill Notation):
C5H12NO5P
CAS Number:
Molecular Weight:
197.13
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Beilstein/REAXYS Number:
2446389
Form:
solid
Quality level:
Product Name
DL-2-Amino-5-phosphonopentanoic acid, solid
form
solid
Quality Level
color
white
solubility
0.1 M NaOH: 4 mg/mL, H2O: 5.6 mg/mL, organic solvents: insoluble
SMILES string
NC(CCCP(O)(O)=O)C(O)=O
InChI
1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
InChI key
VOROEQBFPPIACJ-UHFFFAOYSA-N
Gene Information
rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)
Application
DL-2-Amino-5-phosphonopentanoic acid has been used:
- in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
- used in growth medium for inhibition of electrical activity in the neuronal network
- used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
- used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)
Biochem/physiol Actions
Anticonvulsant; potent and selective NMDA receptor antagonist.
Disclaimer
Hygroscopic
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Product Information Sheet
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Ryota Kobayashi et al.
Frontiers in computational neuroscience, 3, 9-9 (2009-08-12)
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