D0540
DNQX
≥98% (TLC), kainate, quisqualate (non-NMDA) glutamate receptor antagonist, powder
Synonym(s):
6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
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About This Item
Empirical Formula (Hill Notation):
C8H4N4O6
CAS Number:
Molecular Weight:
252.14
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
DNQX, ≥98% (TLC)
Quality Level
assay
≥98% (TLC)
form
powder
SMILES string
[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O
InChI
1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
InChI key
RWVIMCIPOAXUDG-UHFFFAOYSA-N
Gene Information
human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)
mouse ... Gria1(14799)
rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)
Application
DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.
Biochem/physiol Actions
A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.
DNQX is a quinoxaline derivative.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Rei Yamada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3927-3938 (2013-03-01)
Neurons in the nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs from the nucleus magnocellularis (NM) on both sides and process the interaural time differences (ITDs) for sound localization. Sustained inhibition from the superior olivary nucleus
Focal activation of neuronal circuits induced by microstimulation in the visual cortex
Tanaka Y, et al.
Journal of Neural Engineering, 16(3), 036007-036007 (2019)
J Waider et al.
Translational psychiatry, 7(10), e1246-e1246 (2017-10-04)
Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice.