D1507
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride
≥98% (HPLC), solid, L-DOPA precursor
Synonym(s):
Methyl L-DOPA hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C10H13NO4 · HCl
CAS Number:
Molecular Weight:
247.68
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
Product Name
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride, solid
SMILES string
Cl[H].COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1
InChI key
WFGNJLMSYIJWII-FJXQXJEOSA-N
InChI
1S/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/m0./s1
form
solid
color
white to off-white
storage temp.
−20°C
Quality Level
Related Categories
Application
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride has been used:
- in treating 6-hydroxydopamine induced lesions mice serotonin neurons
- in tyrosinase activity in B16F10 skin melanoma cells
- to test its neuroprotective effect in mesencephalic neurons
Biochem/physiol Actions
L-3,4-Dihydroxyphenylalanine methyl ester is a precursor to L-DOPA that crosses the blood-brain barrier. Antiparkinsonian agent L-DOPA methyl ester elicits antitumor functionality in leukemia and melanoma.
Disclaimer
Light sensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Movement disorders : official journal of the Movement Disorder Society, 25(12), 1881-1887 (2010-07-30)
Melevodopa hydrochloride plus carbidopa in effervescent tablets (M/C) is a readily soluble antiparkinsonian tablet formulation. A total of 221 patients with Parkinson's disease and motor fluctuations entered a randomized, double-blind, double-dummy, controlled parallel group study, which compared the effectiveness of
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De Souza Silva MA, et al.
Journal of Neurochemistry, 68(1), 233-239 (1997)
Muriel Geurts et al.
Neuroscience letters, 333(2), 146-150 (2002-11-07)
The role of dopaminergic transmission on striatal mRNA levels of regulators of G protein signalling proteins RGS 2-12 was evaluated by quantitative in situ hybridisation. A single injection of L-dopa (50 mg/kg i.p.) significantly increased the RGS2 mRNA level (by
Kevin W McCairn et al.
Journal of neurophysiology, 101(4), 1941-1960 (2009-01-24)
Competing theories seek to account for the therapeutic effects of high-frequency deep brain stimulation (DBS) of the internal globus pallidus (GPi) for medically intractable Parkinson's disease. To investigate this question, we studied the spontaneous activity of 102 pallidal neurons during
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