I127

ICI 118,551 hydrochloride

Name: ICI 118,551 hydrochloride
Brand: SIGMA

≥98% (HPLC), powder, β2 inverse agonist

Synonym(s):

(2R,3R)-rel-3-isopropylamino-1-(7-methylindan-4-yloxy)-butan-2-ol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₇NO₂ · HCl

CAS Number:

72795-01-8

Molecular Weight:

313.86

UNSPSC Code:

12352200

PubChem Substance ID:

24277782

NACRES:

NA.77

MDL number:

MFCD00153812

Product Name

ICI 118,551 hydrochloride, ≥98% (HPLC), powder

form

powder

storage condition

desiccated

color

white

solubility

H₂O: >10 mg/mL

Quality Level

100

SMILES string

Cl.CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12

InChI

1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1

InChI key

KBXMBGWSOLBOQM-LINSIKMZSA-N

assay

≥98% (HPLC)

Gene Information

human ... ADRB2(154)

Related Categories

Bioactive Small Molecules

Application

ICI 118,551 hydrochloride has been used:

to block β-adrenergic signaling in various experiments
to counteract degradation by endogenous T-lymphocyte monoamine oxidases
to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

Biochem/physiol Actions

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.

ICI 118,551 hydrochloride is a highly selective β₂-adrenoceptor antagonist.

Disclaimer

Hygroscopic

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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beta-Adrenergic-stimulated macrophages: comprehensive localization in the M1-M2 spectrum

Lamkin DM, et al.

Brain, behavior, and immunity, 57(, 338-346 (2016)

Analysis of ICI 118551, a new beta2 blocking drug, and related compounds by RP-HPLC?DAD

Quaglia MG, et al.

Journal of Pharmaceutical and Biomedical Analysis, 10(10-12), 1081-1084 (1992)

Implications of a vasodilatory human monoclonal autoantibody in postural hypotension.

Hongliang Li et al.

The Journal of biological chemistry, 288(42), 30734-30741 (2013-09-18)

Functional autoantibodies to the autonomic receptors are increasingly recognized in the pathophysiology of cardiovascular diseases. To date, no human activating monoclonal autoantibodies to these receptors have been available. In this study, we describe for the first time a β2-adrenergic receptor

alpha-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway

Cai X, et al.

Faseb Journal, 32(1), 488-499 (2017)

Effect of chronic psychological stress on liver metastasis of colon cancer in mice

Zhao L, et al.

PLoS ONE, 10(10), e0139978-e0139978 (2015)

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