P5248

Etidronate disodium hydrate

Name: Etidronate disodium hydrate
Brand: SIGMA

≥97% (NMR), solid

Synonym(s):

Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂H₆Na₂O₇P₂ · xH₂O

CAS Number:

7414-83-7

Molecular Weight:

249.99 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

329820220

UNSPSC Code:

12352200

EC Number:

231-025-7

MDL number:

MFCD00152567

Product Name

Etidronate disodium hydrate, ≥97% (NMR), solid

InChI key

GWBBVOVXJZATQQ-UHFFFAOYSA-L

InChI

1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

SMILES string

[Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O

assay

≥97% (NMR)

form

solid

color

white

mp

>300 °C

solubility

H₂O: ≥10 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

Biochem/physiol Actions

Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC₅₀ = 80 μM) as compared to the nitrogen containing bisphosphonates

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.

Application

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Etidronate protects chronic ocular hypertension induced retinal oxidative stress and promotes retinal ganglion cells growth through IGF-1 signaling pathway

Su J and Huang M

European Journal of Pharmacology, 841, 75-81 (2018)

Uptake of gold (III) from waste gold solution onto biomass-based adsorbents organophosphonic acid functionalized spent buckwheat hulls.

Ping Yin et al.

Bioresource technology, 128, 36-43 (2012-12-01)

Novel biomass-based adsorbents organophosphonic acid functionalized spent buckwheat hulls (OPA-BH) with 60 mesh were successfully employed to adsorb Au(III) ions from simulated wastewater. The adsorption kinetics and isotherms both in unary ion system and in ternary ions system were investigated

A novel monthly dosing regimen of risedronate for the treatment of postmenopausal osteoporosis: 2-year data.

Michael R McClung et al.

Calcified tissue international, 92(1), 59-67 (2012-11-15)

This 2-year trial evaluated the efficacy and tolerability of a monthly oral regimen of risedronate. Postmenopausal women with osteoporosis were randomly assigned to double-blind treatment with risedronate 75 mg on 2 consecutive days each month (2CDM) or 5 mg daily.

Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes

Griffin S, et al.

Biology of Reproduction (2018)

Randomized, double-blinded, placebo-controlled, trial of risedronate for the prevention of bone mineral density loss in nonmetastatic prostate cancer patients receiving radiation therapy plus androgen deprivation therapy.

Richard Choo et al.

International journal of radiation oncology, biology, physics, 85(5), 1239-1245 (2012-12-26)

Androgen deprivation therapy (ADT) has been used as an adjuvant treatment to radiation therapy (RT) for the management of locally advanced prostate carcinoma. Long-term ADT decreases bone mineral density (BMD) and increases the risk of osteoporosis. The objective of this

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