P5248
Etidronate disodium hydrate
≥97% (NMR), solid
Synonym(s):
Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
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About This Item
Empirical Formula (Hill Notation):
C2H6Na2O7P2 · xH2O
CAS Number:
Molecular Weight:
249.99 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
231-025-7
MDL number:
InChI key
GWBBVOVXJZATQQ-UHFFFAOYSA-L
InChI
1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
SMILES string
[Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
assay
≥97% (NMR)
form
solid
color
white
mp
>300 °C
solubility
H2O: ≥10 mg/mL
storage temp.
2-8°C
Quality Level
Related Categories
Application
Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).
Biochem/physiol Actions
Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates
Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Etidronate protects chronic ocular hypertension induced retinal oxidative stress and promotes retinal ganglion cells growth through IGF-1 signaling pathway
Su J and Huang M
European Journal of Pharmacology, 841, 75-81 (2018)
Ping Yin et al.
Bioresource technology, 128, 36-43 (2012-12-01)
Novel biomass-based adsorbents organophosphonic acid functionalized spent buckwheat hulls (OPA-BH) with 60 mesh were successfully employed to adsorb Au(III) ions from simulated wastewater. The adsorption kinetics and isotherms both in unary ion system and in ternary ions system were investigated
Meghan E Faillace et al.
Calcified tissue international, 92(1), 50-58 (2012-11-13)
Mineralizing osteoblasts are regularly used to study osteogenesis and model in vivo bone formation. Thus, it is important to verify that the mineral and matrix being formed in situ are comparable to those found in vivo. However, it has been
Richard Choo et al.
International journal of radiation oncology, biology, physics, 85(5), 1239-1245 (2012-12-26)
Androgen deprivation therapy (ADT) has been used as an adjuvant treatment to radiation therapy (RT) for the management of locally advanced prostate carcinoma. Long-term ADT decreases bone mineral density (BMD) and increases the risk of osteoporosis. The objective of this
Michael R McClung et al.
Calcified tissue international, 92(1), 59-67 (2012-11-15)
This 2-year trial evaluated the efficacy and tolerability of a monthly oral regimen of risedronate. Postmenopausal women with osteoporosis were randomly assigned to double-blind treatment with risedronate 75 mg on 2 consecutive days each month (2CDM) or 5 mg daily.
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