SML0591
Chlorthalidone
≥98% (HPLC)
Synonym(s):
2-Chloro-5(1-hydroxy-3-oxo-1- isoindolinyl) benzenesulfonamide, 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide, Chlortalidone
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(N)c1c(ccc(c1)C2(NC(=O)c3c2cccc3)O)Cl
InChI
1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
InChI key
JIVPVXMEBJLZRO-UHFFFAOYSA-N
Biochem/physiol Actions
Chlorthalidone is a thiazide-like diuretic, an inhibitor of the Na+-Cl- cotransporter.
Chlorthalidone is a thiazide-like diuretic, an inhibitor of the Na+-Cl- cotransporter. Chlorthalidone inhibits sodium ion transport across the renal tubular epithelium increasing the delivery of sodium to the distal renal tubule and indirectly increasing potassium excretion via the sodium-potassium exchange mechanism. Chlorthalidone also promotes Ca++ reabsorption by an unknown mechanism. Several recent comparison studies inidcate that chlorthalidone may be a better drug in preventing cardiovascular events than hydrochlorothiazide.
Still not finding the right product?
Explore all of our products under Chlorthalidone
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 2
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Feras Karadsheh et al.
Current hypertension reports, 14(5), 416-420 (2012-08-14)
Thiazide and thiazide-like diuretics have been widely used as blood pressure-lowering agents for more than 5 decades. However, their use in patients with advanced chronic kidney disease has been limited and often discouraged. The exact mechanism of how thiazide and
Michael Proschan et al.
Statistics in medicine, 32(5), 884-897 (2012-09-11)
The debate over whether certain antihypertensive medications have benefits beyond what would be expected from their blood pressure lowering spurred the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, which randomized 42,418 participants to chlorthalidone (15,255), amlodipine (9048), lisinopril
Brian C Lund et al.
Journal of clinical hypertension (Greenwich, Conn.), 14(9), 623-629 (2012-09-06)
Indirect evidence suggests that chlorthalidone may be more effective than hydrochlorothiazide (HCTZ), but direct comparisons are lacking. Using national Veterans Administrative pharmacy data from 2003 to 2008, the authors performed a retrospective cohort study examining the effectiveness of chlorthalidone and