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T0632

Sodium thioglycolate

Name: Sodium thioglycolate
Brand: SIGMA

≥96.5% (iodometric)

Synonym(s):

Mercaptoacetic acid sodium salt, Thioglycolic acid sodium salt

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About This Item

Linear Formula:

HSCH₂COONa

CAS Number:

367-51-1

Molecular Weight:

114.10

UNSPSC Code:

12352201

NACRES:

NA.25

PubChem Substance ID:

24899901

EC Number:

206-696-4

Beilstein/REAXYS Number:

4569109

MDL number:

MFCD00043386

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Properties

Quality Level

200

assay

≥96.5% (iodometric)

form

powder

color

white to off-white

useful pH range

6.7 (20 °C, 100 g/L)

mp

>300 °C (lit.)

solubility

water: ~609.1 g/L at 20 °C (OECD Test Guideline 105)

storage temp.

−20°C

SMILES string

[Na+].[O-]C(=O)CS

InChI

1S/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1

InChI key

GNBVPFITFYNRCN-UHFFFAOYSA-M

Description

Application

Sodium thioglycolate has been used:

as a growth supplement in enrichment media and to study its effect on Arcobacter
in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
in electron microscopy

Biochem/physiol Actions

Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth.

Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Disclaimer

At room temperature, concentrations over 70% in water tend to form 1-2% thioglycolides per month which hydrolyze to the original free compound when made acidic or alkaline. The 70% solution oxidizes in air but is stable at room temperature when tightly closed. Thioglycolate salts may also lose purity on storage. The exclusion of air does not materially improve stability.