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T8806

Thymopentin

≥97% (HPLC)

Synonym(s):

TP5, Arg-Lys-Asp-Val-Tyr

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About This Item

Empirical Formula (Hill Notation):
C30H49N9O9
CAS Number:
69558-55-0
Molecular Weight:
679.76
UNSPSC Code:
12352209
PubChem Substance ID:
329826886
NACRES:
NA.26
MDL number:
MFCD00214200
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Product Name

Thymopentin, ≥97% (HPLC)

Quality Level

200

assay

≥97% (HPLC)

form

powder

color

white

application(s)

cell analysis

storage temp.

−20°C

SMILES string

CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1

InChI key

PSWFFKRAVBDQEG-YGQNSOCVSA-N

General description

Thymopentin (TP5) is a pentapeptide produced by the epithelial cells of the thymic cortex and medulla. It consists of thymosin α1 (Tα1).

Biochem/physiol Actions

Thymopentin (TP5) is an immunomodulator, resembling the active site of the thymopoietin. TP5 stimulates cellular immune responses such as T-cell formation, natural killer (NK) cell and macrophage activation, generation of cytokines, and activation of B-cell for antibody production. It also mimics the polypeptide environment of the thymus. TP5 is used to treat conditions like immune deficiency, autoimmune diseases, infections, and cancers. It has a short half-life and is rapidly metabolized in the gastrointestinal tract.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCJ1921
SLBQ5860V
SLBN5912V
SLBC4992V
120M1626V

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G Goldstein et al.
Survey of immunologic research, 4 Suppl 1, 1-10 (1985-01-01)
Thymopoietin is a polypeptide hormone of the thymus consisting of 49 amino acids. The pentapeptide thymopentin (TP-5) Arg-Lys-Asp-Val-Tyr, corresponding to amino acids 32-36 of thymopoietin, appears to represent the active site of thymopoietin in that it has all the biological
J Duchateau et al.
Medical oncology and tumor pharmacotherapy, 6(1), 19-23 (1989-01-01)
Immunomodulation is interpreted as a temporary alert in a certain part of the immune system. The activation of immune competent cells is presented as a possible basic mechanism of this phenomenon. In the absence of a primary stimulus, immunomodulation remains
Yan Zhang et al.
International journal of pharmaceutics, 386(1-2), 15-22 (2009-11-10)
Copolymers were synthesized by ring opening polymerization of l- or d-lactide in the presence of dihydroxyl PEG with molar mass of 6000, 12,000 and 20,000, using zinc lactate as catalyst. Bioresorbable hydrogels were obtained by mixing PLLA-PEG-PLLA and PDLA-PEG-PDLA aqueous
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