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About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
L × i.d.:
25 cm × 4.6 mm
Particle size:
5 μm
Matrix active group:
cyclodextrin, beta- phase
Pore size:
100 Å pore size
Matrix:
silica particle platform, fully porous particle
Product Name
Astec® CYCLOBOND I 2000 RSP Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
material
stainless steel column
Quality Level
agency
suitable for USP L45
product line
Astec®
packaging
pkg of 1 ea
manufacturer/tradename
Astec®
parameter
0-50 °C temperature, 172 bar pressure (2500 psi)
technique(s)
HPLC: suitable, LC/MS: suitable
L × I.D.
25 cm × 4.6 mm
matrix
silica particle platform, fully porous particle
matrix active group
cyclodextrin, beta- phase
particle size
5 μm
pore size
100 Å pore size
operating pH
3.5-7
separation technique
chiral
General description
The hydroxyl groups on the surface of the β-cyclodextrin are reacted with (R,S)-propylene oxide to yield a general purpose chiral stationary phase. It has the added property of separating non-aromatic structures such as t-boc amino acids, for which it is a standard methodology.
- Bonded phase: (R,S)-Hydroxypropyl modified β-cyclodextrin
Application
Astec® CYCLOBOND I 2000 RSP chiral HPLC column is basically comprised of native and derivatized β and γ cyclodextrins. It has been used for numerous chiral separations via selectively trapping the organic molecules in the cyclodextrin cavity.
Legal Information
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Rare case of rhabdomyolysis with therapeutic doses of phendimetrazine tartrate.
DK, et al.
American Journal of Therapeutics, 13(2), 175-176 (2006)
C Pham-Huy et al.
Journal of chromatography. B, Biomedical sciences and applications, 700(1-2), 155-163 (1997-12-09)
The simultaneous determination of methadone (Mtd) enantiomers and its major metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), in human urine and serum by enantioselective HPLC using a new Cyclobond 1-2000 RSP column is described. After alkaline extraction from urine or serum with estazolam as
Solid-phase extraction of methadone enantiomers and benzodiazepines in biological fluids by two polymeric cartridges for liquid chromatographic analysis
He, Hua, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 814 (2), 385-391 (2005)