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Merck

1048506

USP

Beclomethasone dipropionate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate

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About This Item

Empirical Formula (Hill Notation):
C28H37ClO7
CAS Number:
5534-09-8
Molecular Weight:
521.04
NACRES:
NA.24
PubChem Substance ID:
329749099
UNSPSC Code:
41116107
MDL number:
MFCD00135613

Key Documents

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Product Name

Beclomethasone dipropionate, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

SMILES string

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C

InChI key

KUVIULQEHSCUHY-XYWKZLDCSA-N

grade

pharmaceutical primary standard

API family

beclometasone

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... NR3C1(2908)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Beclomethasone dipropionate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Beclomethasone Dipropionate Compounded Oral Solution
  • Betamethasone Dipropionate
  • Betamethasone Dipropionate Cream
  • Betamethasone Dipropionate Lotion
  • Betamethasone Dipropionate Ointment
  • Betamethasone Valerate

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Repr. 2 - STOT RE 2

target_organs

Adrenal gland,Immune system,Bone

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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B Davies
The British journal of clinical practice, 47(2), 87-93 (1993-03-01)
Several reports have claimed that beclomethasone dipropionate (BDP) and budesonide (BUD) differ with regard to therapeutic efficacy and associated adverse effects, based either upon clinical data, or upon theoretical considerations. Although long-term comparisons are lacking, the consensus of numerous studies
S E Libretto
Archives of toxicology, 69(8), 509-525 (1995-01-01)
This paper reviews the published toxicity of beclomethasone dipropionate (BDP). BDP is a synthetic glucocorticosteroid which has a powerful local anti-inflammatory effect but little systemic action. It has been developed for both dermatological and inhaled applications. LD50 values and other
A R Boobis
Respiratory medicine, 92 Suppl B, 2-6 (1999-04-08)
The physicochemical and pharmacokinetic characteristics of BDP and budesonide are somewhat different, but the overall result is that both are well suited for use as inhaled corticosteroids. Both BDP and budesonide are metabolized primarily by the liver, with one of
P Chervinsky
Clinical therapeutics, 18(5), 790-796 (1996-09-01)
A new double-strength (84 micrograms/spray) formulation of beclomethasone dipropionate (BDP-ds) as an aqueous suspension has been introduced to control symptoms of allergic rhinitis with once-daily intranasal dosing. This paper reviews the results of three clinical reports which show that BDP-ds
R N Brogden et al.
Drugs, 28(2), 99-126 (1984-08-01)
Inhaled beclomethasone dipropionate is now well established in the management of asthma. Studies conducted over the last decade, and since the drug was previously reviewed in the Journal, have confirmed that inhaled beclomethasone dipropionate 400 to 800 micrograms daily can
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