943509
tert-Butyl (7-aminoheptyl)carbamate
≥95%
Synonym(s):
N-Boc-1,7-diaminoheptane, tert-Butyl 2,8-diaminooctanoate, Boc-DAHpt, Boc-NH-(CH2)7-NH2
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About This Item
Empirical Formula (Hill Notation):
C12H26N2O2
CAS Number:
Molecular Weight:
230.35
MDL number:
NACRES:
NA.21
Assay:
≥95%
Form:
liquid
Quality Segment
assay
≥95%
form
liquid
storage condition
protect from light
color
colorless to pale yellow
functional group
(Ideal for linker-based drug design strategies and conjugation platforms)
storage temp.
2-8°C
SMILES string
O=C(OC(C)(C)C)NCCCCCCCN
InChI
1S/C12H26N2O2/c1-12(2,3)16-11(15)14-10-8-6-4-5-7-9-13/h4-10,13H2,1-3H3,(H,14,15)
InChI key
DTJYPERGUPPXRU-UHFFFAOYSA-N
General description
tert-Butyl (7-aminoheptyl)carbamate is a bifunctional aliphatic linker bearing a primary amine at one end and a Boc-protected amine (carbamate) at the other. The seven-carbon spacer enhances flexibility and hydrophobicity, making it particularly useful as a PROTAC linker and a general-purpose bifunctional building block for bioconjugation and medicinal chemistry applications.
Application
*PROTAC Synthesis: Serves as a flexible linker connecting warhead and E3 ligand components.
*Bioconjugation & Linker Chemistry: Enables conjugation strategies via amide formation, carbamate chemistry, and more.
*Building Block in Medicinal
Chemistry: Useful in constructing bifunctional molecules with spatial separation between reactive groups.
*Bioconjugation & Linker Chemistry: Enables conjugation strategies via amide formation, carbamate chemistry, and more.
*Building Block in Medicinal
Chemistry: Useful in constructing bifunctional molecules with spatial separation between reactive groups.
Features and Benefits
*Orthogonal Functional Groups: Offers both a free primary amine and a protected amine (Boc), enabling sequential or selective derivatization workflows.
*Flexible Hydrophobic Linker (C₇): Enhances structural adaptability in macromolecular constructs like PROTACs or ADCs.
*Versatile Synthetic Utility: Ideal for linker-based drug design strategies and conjugation platforms.
*Flexible Hydrophobic Linker (C₇): Enhances structural adaptability in macromolecular constructs like PROTACs or ADCs.
*Versatile Synthetic Utility: Ideal for linker-based drug design strategies and conjugation platforms.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
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