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943517

(R)-1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

≥95%

Synonym(s):

(1R)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl ester, (2S)- ; (1R)-1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate;, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 2-Piperidinecarboxylic acid, AP 3351

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About This Item

Empirical Formula (Hill Notation):
C30H40N2O6
CAS Number:
195513-96-3
Molecular Weight:
524.65
MDL number:
MFCD12912270
Assay:
≥95%
Form:
solid
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Quality Segment

100

assay

≥95%

form

solid

functional group

amine

storage temp.

2-8°C

SMILES string

O=C(OC(C=1C=CC=C(N)C1)CCC2=CC=C(OC)C(OC)=C2)C3N(C(=O)C(=O)C(C)(C)CC)CCCC3

InChI

1S/C30H40N2O6/c1-6-30(2,3)27(33)28(34)32-17-8-7-12-23(32)29(35)38-24(21-10-9-11-22(31)19-21)15-13-20-14-16-25(36-4)26(18-20)37-5/h9-11,14,16,18-19,23-24H,6-8,12-13,15,17,31H2,1-5H3/t23-,24+/m0/s1

InChI key

IIDSDBBDZNDWCN-BJKOFHAPSA-N

General description

SLF (Synthetic Ligand of FKBP) is a small-molecule ligand designed to bind FKBP12 and related FK506-binding proteins. It mimics immunosuppressant binding (like FK506/rapamycin) but is non-immunosuppressive, making it useful as a chemical biology tool in studies of protein interactions and targeted protein degradation (e.g., PROTAC designs).

Application

  • Chemical biology & target validation: Studies of FKBP function and protein complex formation.
  • PROTAC synthesis: Serves as an FKBP-binding “warhead” or recruiting moiety in degrader constructs.
  • Protein–protein interaction modulation: Used to stabilize or disrupt FKBP-mediated interactions.

Features and Benefits

  • Selective FKBP binder: Engages FKBP proteins, enabling modulation or recruitment in biological systems.
  • Useful in PROTAC/chemical dimerizer designs: Acts as a recruitment handle to bring FKBP-tagged target proteins into proximity with ligases or partners.
  • Versatile research reagent: Applicable in cell-based assays, protein interaction studies, and probe development.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000537294
0000537294

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