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N0560000

Niclosamide (anhydrous)

Name: Niclosamide (anhydrous)
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Niclosamide, 2′,5-Dichloro-4′-nitrosalicylanilide

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₈Cl₂N₂O₄

CAS Number:

50-65-7

Molecular Weight:

327.12

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329818446

MDL number:

MFCD00057597

Beilstein/REAXYS Number:

2820605

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Properties

grade

pharmaceutical primary standard

API family

niclosamide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O

InChI

1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)

InChI key

RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Description

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.

This product is provided as delivered and specified by the issuing Pharmacopoeia. For further information and support, including certificate/ product information sheets, please go to the website of the issuing Pharmacopoeia.

Application

Niclosamide (anhydrous) EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Niclosamide reverses adipocyte induced epithelial-mesenchymal transition in breast cancer cells via suppression of the interleukin-6/STAT3 signalling axis.

Jones Gyamfi et al.

Scientific reports, 9(1), 11336-11336 (2019-08-07)

The microenvironment of breast cancer comprises predominantly of adipocytes. Adipocytes drive cancer progression through the secretion adipocytokines. Adipocytes induce epithelial mesenchymal transition of breast cancer cells through paracrine IL-6/Stat3 signalling. Treatment approaches that can target adipocytes in the microenvironment and

Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells.

Jing-Xuan Pan et al.

Chinese journal of cancer, 31(4), 178-184 (2012-01-13)

Niclosamide, an oral antihelminthic drug, has been used to treat tapeworm infection for about 50 years. Niclosamide is also used as a molluscicide for water treatment in schistosomiasis control programs. Recently, several groups have independently discovered that niclosamide is also

Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.

Min Li et al.

The Journal of biological chemistry, 288(50), 35769-35780 (2013-11-01)

Autophagy can be activated via MTORC1 down-regulation by amino acid deprivation and by certain chemicals such as rapamycin, torin, and niclosamide. Lysosome is the degrading machine for autophagy but has also been linked to MTORC1 activation through the Rag/RRAG GTPase

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