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G1918

Gö 6983

Name: Gö 6983
Brand: SIGMA

≥97%, PKC inhibitor, powder

Synonym(s):

3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₆N₄O₃

CAS Number:

133053-19-7

Molecular Weight:

442.51

UNSPSC Code:

12352200

PubChem Substance ID:

24894916

NACRES:

NA.77

MDL number:

MFCD04040031

Assay:

≥97%

Form:

powder

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Properties

Product Name

Gö 6983, ≥97%

Quality Segment

100

assay

≥97%

form

powder

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1

InChI

1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

InChI key

LLJJDLHGZUOMQP-UHFFFAOYSA-N

Description

Application

GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).

Biochem/physiol Actions

Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC₅₀ = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC₅₀ = 20 mM).

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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