J3770
JNJ7777120
≥98% (HPLC), histamine receptor antagonist, solid
Synonym(s):
1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methyl-piperazine
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About This Item
Empirical Formula (Hill Notation):
C14H16N3OCl
CAS Number:
Molecular Weight:
277.75
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Product Name
JNJ7777120, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: >20 mg/mL, H2O: insoluble
originator
Johnson & Johnson
storage temp.
room temp
SMILES string
CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2
InChI
1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
InChI key
HUQJRYMLJBBEDO-UHFFFAOYSA-N
Application
JNJ7777120 has been used as a histamine-4 receptor antagonist:
- to study its effects on the pro-inflammatory microglia in rats
- to study its effects on the Parkinson′s-like pathology in rat brain
- to study its effects on the histamine receptor interaction in periodontal ligament fibroblasts (PDLF)
Biochem/physiol Actions
JNJ7777120 is a potent, selective non-imidazole H4 histamine receptor antagonist.
JNJ7777120 may exhibit neuroprotective effects against ischemic brain damage. It acts as an anti-inflammatory agent to treat inflammatory diseases. JNJ7777120 is observed to reduce colonic injury, cytokine production, and neutrophil infiltration.
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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