S2876
Spermine tetrahydrochloride
powder or crystals, NMDA agonist/antagonist
Synonym(s):
N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
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About This Item
Empirical Formula (Hill Notation):
C10H26N4 · 4HCl
CAS Number:
Molecular Weight:
348.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-189-8
MDL number:
Beilstein/REAXYS Number:
3911771
Form:
powder or crystals
Quality level:
Product Name
Spermine tetrahydrochloride, powder or crystals
form
powder or crystals
Quality Level
mp
310-311 °C (dec.) (lit.)
solubility
water, high purity: 100 mg/ml
storage temp.
room temp
SMILES string
Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
InChI
1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
InChI key
XLDKUDAXZWHPFH-UHFFFAOYSA-N
Gene Information
human ... GRIN1(2902)
Application
Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.
Used to precipitate DNA from low salt aqueous buffers.
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Spermine, a polyamine, is derived from spermidine and is required for cell growth in eukaryotes. It acts as regulator of gene expression, inhibits DNA damage and protects the cells from damage by acting as free radical scavenger. In proteomics studies, spermine mediates rapid crystallization of DNA-binding proteins.
Preparation Note
Spermine tetrahydrochloride yields clear, colorless to light yellow solution in water at 100 mg/ml.
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Related Content
Instructions
J Griffith et al.
Biochemistry, 24(1), 158-162 (1985-01-01)
The RecA protein of Escherichia coli, whether pure or in a crude cell lysate, will rapidly form small crystals (microcrystals) in the presence of low concentrations of spermidine. We describe the conditions of time, pH, and polyamine concentration over which
E Bergers et al.
Journal of clinical pathology, 49(11), 931-937 (1996-11-01)
Conflicting results have been reported concerning the prognostic value of DNA flow cytometric variables (DNA ploidy, DNA index, %S phase fraction) in breast cancer. Selection bias and differences in treatment may have contributed to these conflicting prognostic results. Differences in
A S Jackson et al.
The British journal of nutrition, 40(3), 497-504 (1978-11-01)
1. Skinfold thickness, body circumferences and body density were measured in samples of 308 and ninety-five adult men ranging in age from 18 to 61 years. 2. Using the sample of 308 men, multiple regression equations were calculated to estimate