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Merck

105228

1,1,1,3,3,3-Hexafluoro-2-propanol

≥99%

Synonym(s):

HFP, Hexafluoroisopropanol

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About This Item

Linear Formula:
(CF3)2CHOH
CAS Number:
920-66-1
Molecular Weight:
168.04
UNSPSC Code:
12352104
NACRES:
NA.22
PubChem Substance ID:
24846695
EC Number:
213-059-4
Beilstein/REAXYS Number:
1841007
MDL number:
MFCD00011651
Assay:
≥99%

Key Documents

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InChI key

BYEAHWXPCBROCE-UHFFFAOYSA-N

InChI

1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H

SMILES string

OC(C(F)(F)F)C(F)(F)F

assay

≥99%

refractive index

n20/D 1.275 (lit.)

bp

59 °C (lit.)

mp

−4 °C (lit.)

density

1.596 g/mL at 25 °C (lit.)

functional group

fluoro, hydroxyl

Quality Level

200

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General description

1,1,1,3,3,3-Hexafluoro-2-propanol is a solution-phase peptide chemistry solvent. This fluorinated polar solvent of high ionizing power facilitates Friedel–Crafts-type reactions, using covalent reagents in the absence of a Lewis acid catalyst. It also enhances the efficiency of rhodium(I)-catalyzed [4+2] intramolecular cycloaddition of ether-tethered alkynyl dienes and [5+2] cycloaddition of alkynyl vinylcyclopropanes. 1,1,1,3,3,3-Hexafluoro-2-propanol clusters catalyzes the epoxidation of cyclooctene and 1-octene with hydrogen peroxide.

Application

1,1,1,3,3,3-Hexafluoro-2-propanol was used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2 Oral

target_organs

Central nervous system

Storage Class

8B - Non-combustible corrosive hazardous materials

flash_point_f

No data available

flash_point_c

No data available

ppe

Faceshields, Gloves, Goggles

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Certificates of Analysis (COA)

Lot/Batch Number
MKDB2729
WXBF7067V
MKCZ4390
WXBF5231V
MKCZ0767

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Rita Sobreiro-Almeida et al.
Materials science & engineering. C, Materials for biological applications, 103, 109866-109866 (2019-07-28)
Kidney diseases are recognized as a major health problem, which affect 10% of the population. Because currently available therapies have many limitations, some tissue engineering strategies have been emerging as promising approaches in this field. In this work, porcine kidneys
Hexafluoroalcohol-functionalized Methacrylate Monomers for Lithographic/Nanopatterning Materials.
Sanders DP, et al.
Material Matters, 6(1), 1-7 (2011)
Kinetic Studies of Olefin Epoxidation with Hydrogen Peroxide in 1, 1, 1, 3, 3, 3-Hexafluoro-2-propanol Reveal a Crucial Catalytic Role for Solvent Clusters.
Berkessel A and Adrio JA.
Advanced Synthesis & Catalysis, 346(2-3), 275-280 (2004)
Akio Saito et al.
The Journal of organic chemistry, 71(17), 6437-6443 (2006-08-12)
In fluorinated alcohols, the cationic Rh(I) species, which is derived from [Rh(COD)Cl]2 and AgSbF6, efficiently catalyzed intramolecular [4+2] cycloaddition reactions of ester-tethered 1,3-diene-8-yne derivatives. The catalytic system was also effective in intramolecular [5+2] cycloaddition reactions of ester-tethered omega-alkynyl vinylcyclopropane compounds.
Lewis acid catalyst free electrophilic alkylation of silicon-capped pi donors in 1,1,1,3,3,3-hexafluoro-2-propanol.
Maxim O Ratnikov et al.
Angewandte Chemie (International ed. in English), 47(50), 9739-9742 (2008-11-05)
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