D6001
Dextran sulfate sodium salt from Leuconostoc spp.
average mol wt >500,000 (dextran starting material), contains 0.5-2.0% phosphate buffer, pH 6-8
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About This Item
biological source
bacterial (Leuconostoc mesenteroides)
Quality Level
form
powder
optical activity
[α]/D 90 to 105 °, c = 6% (w/v) in water
mol wt
average mol wt >500,000 (dextran starting material)
contains
0.5-2.0% phosphate buffer, pH 6-8
composition
Sulfur Content, 16.0-19.0%
color
white to off-white
useful pH range
6.0-8.0 (1% in water)
solubility
H2O: 100 mg/mL
General description
Dextran sulfate is a negatively charged sulfated polysaccharide, which is produced by the esterification of dextran with chlorosulphonic acid. It has antiviral, anticoagulant and adjuvant properties. Dextran is used to treat hemorrhage, burns, surgery and trauma. It enhances blood flow and blocks erythrocyte aggregation. Dextran decreases the risk of thrombosis and postoperative pulmonary emboli. It acts as a ribonuclease inhibitor.
Application
Dextran sulfate sodium salt Leuconostoc spp has been used:
- to delipidate fatty plasma(67)(70)
- to induce inflammatory and carcinogenic response in the distal colon of rodents(68)
- for the preparation of 3,4-ethylenedioxythiophene (EDOT)(69)
Other Notes
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The Molecular Biology of Poliovirus (2012)
Julien Charest et al.
Developmental cell, 55(4), 483-499 (2020-10-02)
Combinatorial action of transcription factors (TFs) with partially overlapping expression is a widespread strategy to generate novel gene-expression patterns and, thus, cellular diversity. Known mechanisms underlying combinatorial activity require co-expression of TFs within the same cell. Here, we describe the
Delipidation of plasma has minimal effects on human butyrylcholinesterase
Onder S, et al.
Frontiers in Pharmacology, 9, 117-117 (2018)