72309
Nicotinic acid
≥99.5% (HPLC)
Synonym(s):
3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3
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About This Item
Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
Molecular Weight:
123.11
UNSPSC Code:
12352209
NACRES:
NA.26
PubChem Substance ID:
EC Number:
200-441-0
Beilstein/REAXYS Number:
109591
MDL number:
biological source
synthetic
Quality Level
assay
≥99.5% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
impurities
≤0.2% water
ign. residue
≤0.05%
color
colorless to white
mp
234-238 °C, 236-239 °C (lit.)
solubility
water: 0.1 g/10 mL, clear, colorless
density
1.473 g/cm3 at 25 °C
SMILES string
OC(=O)c1cccnc1
InChI
1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChI key
PVNIIMVLHYAWGP-UHFFFAOYSA-N
Gene Information
human ... CYP1A2(1544)
rat ... Chrnb2(54239)
General description
Nicotinic acid, also referred as Niacin or vitamin B3, is a water soluble vitamin. It is present in vitamin-enriched bread, liver, meat, fish, poultry, potatoes, green vegetables, peanuts and cereals.
Application
Nicotinic acid has been used as a standard in NAD+ precursor rescue experiments. It has also been used as a vitamin supplement in various culture media such as complete medium (CM) and synthetic medium.
Biochem/physiol Actions
Nicotinic acid or Niacin regulates lipid metabolism by reducing low density lipoprotein (LDL), increasing high-density lipoprotein (HDL) and by inhibiting the progression of atherosclerosis and coronary artery lesions. Niacin deficiency leads to pellagra. In addition to vitamin supplement, niacin is also used as a broad spectrum lipid drug.
Other Notes
Coenzyme and Cofactors, vol 2: Pyridine Nucleotide Coenzymes
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
379.4 °F - closed cup
flash_point_c
193 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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D.Dolphin, R.Poulson, O.Avramovic, eds.
Chemical, Biochemical and Medical Aspects, 759-759 (1987)
Nicotinic Acid Regulates Glucose and Lipid Metabolism Through Lipidindependent Pathways
Liu D, et al.
Current Pharmaceutical Biotechnology, 16(1), 3-10 (2015)
Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review
Carlson LA
Journal of Internal Medicine, 258(2), 94-114 (2005)