PZ0181
PD184352
≥98% (HPLC)
Synonym(s):
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040
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About This Item
Empirical Formula (Hill Notation):
C17H14ClF2IN2O2
CAS Number:
Molecular Weight:
478.66
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥30 mg/mL
storage temp.
room temp
SMILES string
Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F
InChI
1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
InChI key
GFMMXOIFOQCCGU-UHFFFAOYSA-N
Gene Information
human ... MAP2K1(5604), MAP2K2(5605)
Biochem/physiol Actions
PD184352 (CI-1040) is a highly selective MEK (MKK1; MAPK kinase) inhibitor.
PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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