T0251
Thymidine 5′-triphosphate sodium salt
≥96%
Synonym(s):
TTP, dTTP
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About This Item
Empirical Formula (Hill Notation):
C10H16N2O14P3Na
CAS Number:
Molecular Weight:
504.15
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
Assay:
≥96%
Storage temp.:
−20°C
Product Name
Thymidine 5′-triphosphate sodium salt, ≥96%
SMILES string
[NaH].[P](=O)(O[P](=O)(OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C)O)(O[P](=O)(O)O)O
InChI
1S/C10H17N2O14P3.Na.H/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18);;
InChI key
KAELIXTVSANDSE-UHFFFAOYSA-N
assay
≥96%
shipped in
dry ice
storage temp.
−20°C
Quality Level
Related Categories
Application
Thymidine 5′-triphosphate (dTTP) is one of the four natural deoxynucleotides, along with deoxyadenosine 5′-triphosphate (dATP), deoxyguanosine 5′-triphosphate (dGTP) and deoxycytosine 5′-triphosphate (dCTP) used for the biosynthesis of deoxyribonucleic acids by DNA polymerases and reverse transcriptases. Deoxy-TTP may also be used as a substrate to study the specificity and kinetics of thymidine-triphosphatase(s) (EC 3.6.1.39) and other dTTP hydrolyzing activities.
Thymidine 5′-triphosphate sodium salt has been used:
- in the quenching ability test for dual-aptamer and multiple-nucleotide detection based on a multiple-aptamer/GO-nS complex
- to study protein-metabolite interactions in the central metabolism of Escherichia coli
- in a polymerase chain reaction (PCR) product formation using AM-toxin primers
Biochem/physiol Actions
Thymidine triphosphate is a building block of DNA. It acts as an allosteric regulator of other nucleotides′ metabolism.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Christina Jensen et al.
Scientific reports, 7(1), 2830-2830 (2017-06-08)
In the absence of a validated correlate of protection or robust animal models for human tuberculosis, Mycobacterial growth inhibition assays (MGIAs) aim to assess vaccines ability to inhibit mycobacterial growth in-vitro. We optimised a reproducible murine splenocyte MGIA based on
Hidenori Nakaoka et al.
The Journal of biological chemistry, 287(1), 619-627 (2011-11-17)
The Ctc1-Stn1-Ten1 (CST) complex is an RPA (replication protein A)-like protein complex that binds to single-stranded (ss) DNA. It localizes at telomeres and is involved in telomere end protection in mammals and plants. It is also known to stimulate DNA
Merel M C Lambregts et al.
PloS one, 14(1), e0208819-e0208819 (2019-01-03)
Blood cultures are considered the gold standard to distinguish bacteremia from non-bacteremic systemic inflammation. In current clinical practice, bacteraemia is considered unlikely if blood cultures have been negative for 48-72 hours. Modern BC systems have reduced this time-to-positivity (TTP), questioning
Interconversion of deoxyribonucleotides
Henderson JF and A.R.P.Paterson
Nucleosides, 247-259 (2018)
Xue-Ke Zhao et al.
PloS one, 11(12), e0167451-e0167451 (2016-12-03)
Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD). Tristetraprolin (TTP) is implicated in regulation of TNF-α expression; however, whether TTP is involved in cigarette smoke-induced TNF-α expression has
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