trans-Ferulic acid

Name: <I>trans</I>-Ferulic acid
Brand: ALDRICH

99%

Synonym(s):

trans-4-Hydroxy-3-methoxycinnamic acid, Ferulic acid

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All Photos(3)

About This Item

Linear Formula:

HOC₆H₃(OCH₃)CH=CHCO₂H

CAS Number:

537-98-4

Molecular Weight:

194.18

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24847872

EC Number:

208-679-7

Beilstein/REAXYS Number:

1570363

MDL number:

MFCD00004400

Product Name

trans-Ferulic acid, 99%

InChI key

KSEBMYQBYZTDHS-HWKANZROSA-N

InChI

1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+

SMILES string

OC(/C=C/C1=CC(OC)=C(O)C=C1)=O

assay

99%

form

powder
powder and chunks

mp

168-172 °C (lit.)

functional group

carboxylic acid

Quality Level

200

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Application

trans-Ferulic acid was used for esterification of methacrylated dextran. It was also used to study the effect of oral administration of trans-ferulic acid to c57BL mice on ethanol-induced liver injury. Furthermore, it has been used in the synthesis of new biocompatible antioxidant polymers linking trans-ferulic acid.

Biochem/physiol Actions

Hydroxycinnamic acid found in plant-based foods. Antioxidant.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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The effect of trans-ferulic acid and gamma-oryzanol on ethanol-induced liver injury in C57BL mouse.

Chatchawan Chotimarkorn et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 15(11), 951-958 (2008-04-22)

The effects of the oral administration of trans-ferulic acid and gamma-oryzanol (mixture of steryl ferulates) with ethanol (5.0 g per kg) for 30 days to c57BL mice on ethanol-induced liver injury were investigated. Preventions of ethanol-induced liver injury by trans-ferulic

A novel dextran hydrogel linking trans-ferulic acid for the stabilization and transdermal delivery of vitamin E.

Roberta Cassano et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 72(1), 232-238 (2008-11-04)

Long-term exposure of the skin to UV light causes degenerative effects, which can be minimized by using antioxidant formulations. The major challenge in this regard is that a significant amount of antioxidant should reach at the site for effective photoprotection.

Antioxidant effect of ferulic acid in isolated membranes and intact cells: synergistic interactions with alpha-tocopherol, beta-carotene, and ascorbic acid.

Sonia Trombino et al.

Journal of agricultural and food chemistry, 52(8), 2411-2420 (2004-04-15)

Although an antioxidant mechanism has been involved in the beneficial effects of ferulic acid in human diseases, there are few reports on the antioxidant properties of this compound in isolated membranes and intact cells. Here, we evaluated the ability of

Manipulation of Guaiacyl and Syringyl Monomer Biosynthesis in an Arabidopsis Cinnamyl Alcohol Dehydrogenase Mutant Results in Atypical Lignin Biosynthesis and Modified Cell Wall Structure.

Nickolas A Anderson et al.

The Plant cell, 27(8), 2195-2209 (2015-08-13)

Modifying lignin composition and structure is a key strategy to increase plant cell wall digestibility for biofuel production. Disruption of the genes encoding both cinnamyl alcohol dehydrogenases (CADs), including CADC and CADD, in Arabidopsis thaliana results in the atypical incorporation

Rye bran bread intake elevates urinary excretion of ferulic acid in humans, but does not affect the susceptibility of LDL to oxidation ex vivo.

Helle Harder et al.

European journal of nutrition, 43(4), 230-236 (2004-08-17)

Rye bread contributes an important part of the whole grain intake in the Scandinavian diet. Ferulic acid is the major phenolic compound in rye bran and is an antioxidant in vitro and may, therefore, contribute to cardioprotective effects of whole

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