162493
4-Fluorobenzylamine
97%
Synonym(s):
(4-Fluorophenyl)methanamine, 1-(4-Fluorophenyl)methanamine, 4-Fluorobenzenemethanamine, [(4-Fluorophenyl)methyl]amine, p-Fluorobenzylamine
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About This Item
Linear Formula:
FC6H4CH2NH2
CAS Number:
Molecular Weight:
125.14
NACRES:
NA.22
PubChem Substance ID:
eCl@ss:
39040409
UNSPSC Code:
12352100
EC Number:
205-430-4
MDL number:
Beilstein/REAXYS Number:
636501
Assay:
97%
Form:
liquid
Quality Level
assay
97%
form
liquid
refractive index
n20/D 1.512 (lit.)
bp
183 °C (lit.)
density
1.095 g/mL at 25 °C (lit.)
functional group
amine, fluoro
SMILES string
NCc1ccc(F)cc1
InChI
1S/C7H8FN/c8-7-3-1-6(5-9)2-4-7/h1-4H,5,9H2
InChI key
IIFVWLUQBAIPMJ-UHFFFAOYSA-N
Gene Information
human ... AOC3(8639)
mouse ... Aoc3(11754)
General description
[18F]4-fluorobenzylamine reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate. It is an important building block for the synthesis of 18F-labeled compounds.
Application
4-Fluorobenzylamine was used in the synthesis of new tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
150.8 °F - closed cup
flash_point_c
66 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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3'-Aza-2'-[18F]fluorofolic acid.
Leung K
SourceMolecular Imaging and Contrast Agent Database (MICAD) [Internet] (2013)
Ingrid Koslowsky et al.
Organic & biomolecular chemistry, 8(20), 4730-4735 (2010-08-27)
A novel synthesis of 4-[(18)F]fluorobenzylamine ([(18)F]FBA) by means of transition metal-assisted sodium borohydride reduction of 4-[(18)F]fluorobenzonitrile ([(18)F]FBN) is described. This approach could successfully be extended to borohydride exchange resin (BER) enabling a viable option for use in automated syntheses. [(18)F]FBA
Walkiria Schlindwein et al.
Dalton transactions (Cambridge, England : 2003), (10)(10), 1313-1321 (2006-03-01)
New tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands derived from maltol (3-hydroxy-2-methyl-4-pyrone) or ethylmaltol (2-ethyl-3-hydroxy-4-pyrone), including a variety of N-aryl (phenyl, 4'-tolyl, 4'-(n-butyl)phenyl, 4'-(n-hexyl)phenyl) and N-benzyl (4'-methylbenzyl, 4'-fluorobenzyl and 4'-(trifluoromethyl)benzylamine) substituents on the nitrogen atom of the pyridinone ring, have been prepared.