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Merck

07-328

Anti-acetyl-Histone H4 (Lys8) Antibody

serum, Upstate®

Synonym(s):

H4K8Ac, Histone H4 (acetyl K8)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-acetyl-Histone H4 (Lys8) Antibody, serum, Upstate®

biological source

rabbit

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, Saccharomyces cerevisiae

manufacturer/tradename

Upstate®

technique(s)

ChIP: suitable (ChIP-seq)
dot blot: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_175054

UniProt accession no.

P62805

shipped in

wet ice

target post-translational modification

acetylation (Lys8)

Quality Level

100

Gene Information

human ... H4C1(8359)

Analysis Note

Control
Sodium butyrate treated HeLa cells
routinely evaluated by immunoblot on acid extracts from sodium butyrate treated HeLa cells

Application

Use Anti-acetyl-Histone H4 (Lys8) Antibody (Rabbit Polyclonal Antibody) validated in ChIP, IP, WB, DB, ChIP-seq to detect acetyl-Histone H4 (Lys8) also known as H4K8Ac, Histone H4 (acetyl K8).

General description

Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the ′beads on a string′ structure.



The N-terminal tail of histone H4 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
10 kDa

Immunogen

Peptide corresponding to amino acids 3-13 of yeast Histone H4 (RGKGGAcKGLGKG-C) in which lysine 8 is acetylated.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Liposomes loaded with histone deacetylase inhibitors for breast cancer therapy.
Urbinati G, Marsaud V, Plassat V, Fattal E, Lesieur S, Renoir JM
International Journal of Pharmaceutics null
Cc Chemokine Ligand 2 and Lif Cooperatively Promote Pluripotency in Mouse Induced Pluripotent Cells.
Hasegawa Y, Takahashi N, Forrest AR, Shin JW, Kinoshita Y, Suzuki H, Hayashizaki Y
Stem Cells null
Shivakumar Subbanna et al.
The international journal of neuropsychopharmacology, 18(5) (2015-01-23)
Ethanol exposure to rodents during postnatal day 7 (P7), which is comparable to the third trimester of human pregnancy, induces long-term potentiation and memory deficits. However, the molecular mechanisms underlying these deficits are still poorly understood. In the present study
Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl.
Vaughan, CA; Singh, S; Windle, B; Yeudall, WA; Frum, R; Grossman, SR; Deb, SP; Deb, S
Genes & Cancer null
Anne-Lise Steunou et al.
Molecular and cellular biology, 36(22), 2768-2781 (2016-10-30)
Recognition of histone marks by reader modules is thought to be at the heart of epigenetic mechanisms. These protein domains are considered to function by targeting regulators to chromosomal loci carrying specific histone modifications. This is important for proper gene
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Global Trade Item Number

SKUGTIN
07-32804053252324789

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