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Merck

PHR1244

Lindane

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

gamma-hexachlorocyclohexane, γ-BHC, 1α,2α,3β,4α,5α,6β-Hexachlorocyclohexane

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About This Item

Empirical Formula (Hill Notation):
C6H6Cl6
CAS Number:
58-89-9
Molecular Weight:
290.83
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823248
EC Number:
200-401-2
Beilstein/REAXYS Number:
1907337
MDL number:
MFCD00135947

Key Documents

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Product Name

Lindane, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

JLYXXMFPNIAWKQ-GNIYUCBRSA-N

InChI

1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5+,6+

SMILES string

Cl[C@H]1[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@@H]1Cl

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1367504

API family

lindane

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

113-115 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

Lindane may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using gas chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Lindane is an organochlorine chemical, widely used as an agricultural insecticide and it also finds applications for the pharmaceutical treatment of infestations of lice and scabies.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9048 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous Determination by Gas Chromatography of Lindane and Carbaryl in Combined Formulations
Sen I, et al.
Journal of Chemistry, 8(1), 391-399 (2011)
L A Videla et al.
Free radical biology & medicine, 9(2), 169-179 (1990-01-01)
The development of an oxidative stress condition in the liver by lindane intoxication is discussed as a possible hepatotoxic mechanism of the insecticide. Lindane is metabolized by liver microsomal enzymes to a variety of metabolites, which are susceptible of conjugation
Cristina Becerra-Castro et al.
Environmental pollution (Barking, Essex : 1987), 178, 202-210 (2013-04-16)
The performance of Cytisus striatus in association with different microbial inoculant treatments on the dissipation of the insecticide hexachlorocyclohexane (HCH) was studied. Two soils with different organic matter (A and B soil) content were spiked with 0 or 65 mg HCH kg(-1).
John Vijgen et al.
Environmental science and pollution research international, 18(2), 152-162 (2010-11-26)
Hexachlorocyclohexane (HCH) isomers (α-, β- and γ- (Lindane)) were recently included as new persistent organic pollutants (POPs) in the Stockholm Convention, and therefore, the legacy of HCH and Lindane production became a contemporary topic of global relevance. This article wants
Microbial degradation of the pesticide lindane (gamma-hexachlorocyclohexane).
B K Singh et al.
Advances in applied microbiology, 47, 269-298 (2003-07-25)
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