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Merck

A1346

ASB-14

Synonym(s):

3-[N,N-Dimethyl(3-myristoylaminopropyl)ammonio]propanesulfonate, Amidosulfobetaine-14

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About This Item

Empirical Formula (Hill Notation):
C22H46N2O4S
CAS Number:
216667-08-2
Molecular Weight:
434.68
UNSPSC Code:
12161902
NACRES:
NA.28
MDL number:
MFCD03456122

SMILES string

[S](=O)(=O)([O-])CCC[N+](CCCNC(=O)CCCCCCCCCCCCC)(C)C

InChI

1S/C22H46N2O4S/c1-4-5-6-7-8-9-10-11-12-13-14-17-22(25)23-18-15-19-24(2,3)20-16-21-29(26,27)28/h4-21H2,1-3H3,(H-,23,25,26,27,28)

InChI key

UTSXERRKRAEDOV-UHFFFAOYSA-N

description

zwitterionic

assay

≥95.0% (HPLC)

form

powder

mol wt

average mol wt >10,000

aggregation number

≥23

storage temp.

2-8°C

Quality Level

200

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Analysis Note

ASB-14 (amidosulfobetaine-14), a membrane solubilizing zwitterionic detergent (medium chain amidosulfobetaine surfactant), may be used in protein and macromolecule research for the preparative extraction and solubilization of proteins for separation and analysis by methods such as 2D-electrophoresis. ASB-14 may be used in tissue engineering for antigen removal (AR) for xenogeneic scaffold generation. ASB-14 may be used to develop and study zwitterionic micelles.

Application

ASB-14 has been used as a component of rehydration buffer for proteomic sample preparation from Leishmania donovani.
Zwitterionic detergent. Useful for solubilization of proteins, including membrane proteins, for 2D electrophoresis.

Biochem/physiol Actions

ASB-14 is useful in proteasome extraction especially for the membrane associated proteins. Along with CHAPS (3-(3-cholamidopropyl)dimethylammonio)-1-propanesulfonate), it is employed in protein solubilization even in the presence of thiourea.

General description

ASB-14 comprises alkyl tails and amidosulfobetaine headgroup.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000484431
0000484431
0000382414
0000382414
SLCN7658

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Nityakalyani Srinivas et al.
Science (New York, N.Y.), 327(5968), 1010-1013 (2010-02-20)
Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We synthesized a family of peptidomimetic antibiotics based on the antimicrobial peptide protegrin I. Several rounds of optimization gave a
Thermodynamic and structural characterization of zwitterionic micelles of the membrane protein solubilizing amidosulfobetaine surfactants ASB-14 and ASB-16
D Andrea MG, et al.
Langmuir, 27(13), 8248-8256 (2011)
Francisella t ularensis Proteome: Low Levels of ASB-14 Facilitate the Visualization of Membrane Proteins in Total Protein Extracts
Twine SM, et al.
Journal of Proteome Research, 4(5), 1848-1854 (2005)
Protein Sample Preparation for Proteomic Analysis in Leishmania donovani
Alexandros A and Despina S
Bio-protocol, 4(5), 70-75 (2014)
Maelene L Wong et al.
Acta biomaterialia, 9(5), 6492-6501 (2013-01-17)
The ability of residual antigens on decellularized tissue to elicit the immune response upon implantation motivates development of a more rigorous antigen removal (AR) process for xenogeneic scaffold generation. Antigen removal strategies promoting solubilization of hydrophilic proteins (predominantly cytoplasmic) enhance
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