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Merck

A4188

N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin

≥97% (HPLC), powder

Synonym(s):

Ac-IETD-AMC

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About This Item

Empirical Formula (Hill Notation):
C31H41N5O12
Molecular Weight:
675.68
NACRES:
NA.32
PubChem Substance ID:
24890834
UNSPSC Code:
12352209
MDL number:
MFCD01630896

Key Documents

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Product Name

N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin, ≥97% (HPLC), powder

InChI

1S/C31H41N5O12/c1-6-14(2)26(32-17(5)38)30(46)34-20(9-10-23(39)40)28(44)36-27(16(4)37)31(47)35-21(13-24(41)42)29(45)33-18-7-8-19-15(3)11-25(43)48-22(19)12-18/h7-8,11-12,14,16,20-21,26-27,37H,6,9-10,13H2,1-5H3,(H,32,38)(H,33,45)(H,34,46)(H,35,47)(H,36,44)(H,39,40)(H,41,42)/t14-,16+,20-,21-,26-,27-/m0/s1

SMILES string

CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1

InChI key

ZYTCBVQZQSFKHQ-HGZCCCDHSA-N

assay

≥97% (HPLC)

form

powder

color

white

solubility

DMSO/DMF: 1 mg/mL

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CARD8(22900), CASP8(841), CASP8AP2(9994), CFLAR(8837), GZMB(3002)
mouse ... CFLAR(117279), GZMB(171528)
rat ... CASP8(12370), CFLAR(12633), GZMB(14939), RGD1561819(502004), RGD1562700(502007)

Application

Fluorogenic substrate for caspase 8 and granzyme B.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF9588
BCBD3703V
BCBM1321V
BCBF2497V
116K1208

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