C1879

Choline chloride

Name: Choline chloride
Brand: SIGMA

synthetic, ≥98%, Choline acetyltransferase substrate, powder or crystals

Synonym(s):

(2-Hydroxyethyl)trimethylammonium chloride

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About This Item

Linear Formula:

(CH₃)₃N(Cl)CH₂CH₂OH

CAS Number:

67-48-1

Molecular Weight:

139.62

NACRES:

NA.77

PubChem Substance ID:

57653990

UNSPSC Code:

12352200

EC Number:

200-655-4

MDL number:

MFCD00011721

Beilstein/REAXYS Number:

3563126

Product Name

Choline chloride, ≥98%

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

SMILES string

[Cl-].C[N+](C)(C)CCO

biological source

synthetic

assay

≥98%

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

color

colorless to white

mp

302-305 °C (dec.) (lit.)

Quality Level

200

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Related Categories

Bioactive Small Molecules

Biochemicals

Cell Culture Supplements & Reagents

Vitamins

Application

Choline chloride has been used:

as a substrate for measuring choline oxidase enzyme activity using fluorescence measurements
as a component of non-physiological buffers for testing calcium based inhibition of cytochrome c oxidaseP
as a component of perfusate solution for studying arterial pressure in jejunum samples

Biochem/physiol Actions

Choline chloride treatment of radish seeds modulates phosphatidylcholine and phosphatidylethanolamine levels. It elicits hepatoprotective effects and modulates methyl carbon based metabolic pathways.

General description

Choline acetyltransferase substrate

Choline chloride is the synthetic form of vitamin B4, choline and is a common poultry feed.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Choline and methionine differentially alter methyl carbon metabolism in bovine neonatal hepatocytes

Chandler TL and White HM

PLoS ONE, 12(2), e0171080-e0171080 (2017)

Effect of choline chloride on the lipid content and composition in the leaves of principal magnetically-oriented radish types

Novitskaya GV, et al.

Russian Journal of Plant Physiology, 51(3), 361-371 (2004)

Cytochrome c oxidase inhibition by calcium at physiological ionic composition of the medium: Implications for physiological significance of the effect

Vygodina T, et al.

Biochimica et Biophysica Acta - Bioenergetics, 1858(12), 982-990 (2017)

Evaluation of polyherbal formulation and synthetic choline chloride on choline deficiency model in broilers: implications on zootechnical parameters, serum biochemistry and liver histopathology

Selvam R, et al.

Asian-Australasian Journal of Animal Sciences, 31(11), 1795-1795 (2018)

An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat

Lucas ML and Morrison JD

Physiological Reports, 3(5) (2015)

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