C7629
L-Citrulline
≥98% (TLC)
Synonym(s):
(S)-2-Amino-5-ureidopentanoic acid, L-2-Amino-5-ureidovaleric acid
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About This Item
Empirical Formula (Hill Notation):
C6H13N3O3
CAS Number:
Molecular Weight:
175.19
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
206-759-6
MDL number:
Beilstein/REAXYS Number:
1725416
Product Name
L-Citrulline, ≥98% (TLC)
Quality Level
assay
≥98% (TLC)
form
powder
color
white to off-white
application(s)
detection
SMILES string
N[C@@H](CCCNC(N)=O)C(O)=O
InChI
1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1
InChI key
RHGKLRLOHDJJDR-BYPYZUCNSA-N
Application
L-Citrulline has been used in ultra-performance liquid chromatography to validate, metabolites involved in the coordination of metamorphic processes.
Biochem/physiol Actions
Intermediate in the production of nitric oxide from L-arginine by NO synthetase.
L-Citrulline, when orally administered is found to ameliorate the condition of sickle cell disease in humans. L-citrulline can be a replacement for L-arginine administration in case of defective NO synthetase. L-Citrulline supplementation is found to fulfill the purpose of NO-dependent signaling.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits.
Hayashi T
Proceedings of the National Academy of Sciences of the USA null
Nu-Hydroxy-L-arginine Is an Intermediate in the Biosynthesis of Nitric Oxide from L-Arginin
Dennis J. Stuehr
The Journal of Biological Chemistry, 266, 6259-6263 (1991)
Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
Schwedhelm E
British Journal of Clinical Pharmacology, 65(1), 51-59 (2008)