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D0633

7-(2,3-Dihydroxypropyl)theophylline

Name: 7-(2,3-Dihydroxypropyl)theophylline
Brand: SIGMA

PDE inhibitor, powder

Synonym(s):

7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, Diprophylline, Dyphylline

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₄O₄

CAS Number:

479-18-5

Molecular Weight:

254.24

NACRES:

NA.77

PubChem Substance ID:

24893280

UNSPSC Code:

41106305

EC Number:

207-526-1

MDL number:

MFCD00005759

Beilstein/REAXYS Number:

284563

Form:

powder

Quality level:

200

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Properties

Product Name

7-(2,3-Dihydroxypropyl)theophylline,

form

powder

Quality Level

200

mp

161-162 °C (lit.)

SMILES string

CN1C(=O)N(C)c2ncn(CC(O)CO)c2C1=O

InChI

1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3

InChI key

KSCFJBIXMNOVSH-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Description

Biochem/physiol Actions

7-(2,3-Dihydroxypropyl)theophylline is also called as dyphylline. Dyphylline serves as a bronchodilator and aids in better air flow through the lungs. It reduces the symptoms of chronic lung disorder such as asthma and bronchitis.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography (2017)

Validation of Raman spectroscopic procedures in agreement with ICH guideline Q2 with considering the transfer to real time monitoring of an active coating process.

Joshua Müller et al.

Journal of pharmaceutical and biomedical analysis, 53(4), 884-894 (2010-07-20)

A multivariate model was constructed by correlating Raman spectral data with coated amount of the API diprophylline using Partial Least Squares. In agreement with ICH guideline Q2 the method was validated in order to achieve the requirement of demonstrating that

The AARP Guide to Pills: Essential Information on More Than 1,200 Prescription and Nonprescription Medicines, Including Generics, 302-302 (2006)

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