D7815
R(−)-Denopamine
≥98% (HPLC), β1 adrenoceptor agonist, powder
Synonym(s):
(−)-α-(3,4-Dimethoxyphenethylaminomethyl)-4-hydroxybenzylalcohol
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About This Item
Empirical Formula (Hill Notation):
C18H23NO4
CAS Number:
Molecular Weight:
317.38
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
R(−)-Denopamine, ≥98% (HPLC), powder
SMILES string
COc1ccc(CCNC[C@H](O)c2ccc(O)cc2)cc1OC
InChI key
VHSBBVZJABQOSG-INIZCTEOSA-N
InChI
1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: 10 mg/mL, clear
H2O: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADRB1(153)
Related Categories
Application
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
Biochem/physiol Actions
β1-adrenoceptor agonist.
Denopamine is a cardiotonic drug.
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Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Weak arrhythmogenic property of the new cardiotonic agent denopamine in dogs: comparison with catecholamines
NARITA H, et al.
Japanese Journal of Pharmacology, 41(3), 335-344 (1986)
Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment.
Dainari Nakajima et al.
International journal of cardiology, 108(2), 281-283 (2005-05-26)
Barry M Trost et al.
Organic letters, 4(16), 2621-2623 (2002-08-03)
[reaction: see text] Syntheses of variously modified ligands for the dinuclear zinc catalysts for the asymmetric aldol and nitroaldol (Henry) reactions are reported. Catalytic enantioselective nitroaldol reactions promoted by these modified ligands led to efficient syntheses of the beta-receptor agonists
H Kurosawa et al.
Japanese journal of pharmacology, 72(4), 325-333 (1996-12-01)
Influence of cardiotonic agents on the prognosis of heart failure depends on the individual therapeutic agents, and favorable and unfavorable effects of these agents have been reported in clinical trials. We studied the effect of the cardiotonic agent denopamine on
M Hirayama et al.
Rinsho shinkeigaku = Clinical neurology, 40(8), 787-790 (2001-02-24)
In 1993, we reported the pathophysiology of postprandial hypotension (PPH) in patients with sympathetic dysfunction: a fall of BP resulted from both excess systemic vasodilation and lack of compensatory increase of cardiac output and vascular resistance in the leg arteries.
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