F4641
Anti-Human IgG3−FITC antibody, Mouse monoclonal
clone HP-6050, purified from hybridoma cell culture
Synonym(s):
Monoclonal Anti-Human IgG3
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
FITC conjugate
Clone:
HP-6050, monoclonal
Application:
DIBA, PIFA
Citations:
17
biological source
mouse
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
secondary antibodies
clone
HP-6050, monoclonal
form
buffered aqueous solution
storage condition
protect from light
technique(s)
dot immunobinding: 1:64, particle immunofluorescence: 1:8
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
General description
Human Immunoglobulin G consists of four subclasses, namely IgG1, IgG2, IgG3, and IgG4, named γ1, γ2, γ3, and γ4, respectively. The primary structure of the antibody contains disulfide bonds involved in linking the two heavy chains,and linking the heavy and light chains. IgG3, a pro-inflammatory antibody, appears first in the course of a viral infection and induces effector functions.
Application
Monoclonal Anti-Human IgG3-FITC antibody produced in mouse has been used in immunohistochemistry and indirect immunofluorescence.
Biochem/physiol Actions
The antibody is specific for human IgG3 and is non-reactive with other IgG subclasses. This clone has been recommended by the IUIS/WHO study for its specificity and reactivity in a wide range of assay protocols and techniques.
Physical form
Solution in 0.01 M phosphate buffer, pH 8.0, containing 1% inactivated bovine serum albumin and 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month.
For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
Other Notes
In order to obtain best results, it is recommended that each individual user determine working dilutions by titration assay.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Erdem Tüzün et al.
Acta neuropathologica, 118(6), 737-743 (2009-08-15)
We report the immunopathological analysis of the brain and tumor of two patients who died of anti-NMDAR-associated encephalitis, and of the tumor of nine patients who recovered. Findings included prominent microgliosis and deposits of IgG with rare inflammatory infiltrates in
Seroprevalence of human herpesvirus 6 in Andino Pune?os (Argentina)
Romagnoli, Pablo Alberto, et al.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 669-672 (2000)
Antibody structure, instability, and formulation.
Wang W, et al.
Journal of Pharmaceutical Sciences, 96(1), 1-26 (2007)
IgG Subclasses and Allotypes: From Structure to Effector Functions
Gestur V, et al.
Frontiers in Immunology (2014)
Tiffany N Caza et al.
Kidney360, 1(6), 491-500 (2020-04-21)
Common variable immunodeficiency (CVID) is one of the most common primary immunodeficiency syndromes, affecting one in 25,000-50,000 people. Renal insufficiency occurs in approximately 2% of patients with CVID. To date, there are no case series of renal biopsies from patients
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